Thioamides in the collagen triple helix? #MMPMID25967743
Newberry RW; VanVeller B; Raines RT
Chem Commun (Camb) 2015[Jun]; 51 (47): 9624-7 PMID25967743show ga
To probe noncovalent interactions within the collagen triple helix, backbone amides were replaced with a thioamide isostere. This subtle substitution is the first in the collagen backbone that does not compromise thermostability. A triple helix with a thioamide as a hydrogen bond donor was found to be more stable than triple helices assembled from isomeric thiopeptides.