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10.1016/j.cell.2015.04.030 http://scihub22266oqcxt.onion/10.1016/j.cell.2015.04.030 C4448932!4448932 !26000485     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26000485 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell 2015 ; 161 (5 ): 1124-1137 Nephropedia Template TP {{tp|p=26000485 |t=2015. Chromosomes Progress to Metaphase in Multiple Discrete Steps via Global Compaction/Expansion Cycles |pdf=|usr=}}{{26000485 }} gab.com Text Chromosomes Progress to Metaphase in Multiple Discrete Steps via Global Compaction/Expansion Cycles JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=26000485 #FOAvip Mammalian mitotic chromosome morphogenesis was analyzed by 4D live-cell and snapshot deconvolution fluorescence imaging. Prophase chromosomes, whose organization was previously unknown, are revealed to comprise co-oriented sister linear loop arrays displayed along a single, peripheral, regularly kinked topoisomerase II/cohesin/condensin II axis. Thereafter, rather than smooth, progressive compaction as generally envisioned, progression to metaphase is a discontinuous process involving chromosome expansion as well as compaction. At late prophase, dependent on topoisomerase II and with concomitant cohesin release, chromosomes expand, axes split and straighten, and chromatin loops transit to a radial disposition around now-central axes. Finally, chromosomes globally compact, giving the metaphase state. These patterns are consistent with the hypothesis that the molecular events of chromosome morphogenesis are governed by accumulation and release of chromosome stress, created by chromatin compaction and expansion. Chromosome state could evolve analogously throughout the cell cycle. Twit Text FOAVip Chromosomes Progress to Metaphase in Multiple Discrete Steps via Global Compaction/Expansion Cycles ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=26000485 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26000485 #FOAvip English Wikipedia <ref>{{Cite pmid|26000485 }}</ref> Chromosomes Progress to Metaphase in Multiple Discrete Steps via Global Compaction/Expansion Cycles #MMPMID26000485 Liang Z ; Zickler D ; Prentiss M ; Chang FS ; Witz G ; Maeshima K ; Kleckner N Cell 2015[May]; 161 (5 ): 1124-1137 PMID26000485 show ga Mammalian mitotic chromosome morphogenesis was analyzed by 4D live-cell and snapshot deconvolution fluorescence imaging. Prophase chromosomes, whose organization was previously unknown, are revealed to comprise co-oriented sister linear loop arrays displayed along a single, peripheral, regularly kinked topoisomerase II/cohesin/condensin II axis. Thereafter, rather than smooth, progressive compaction as generally envisioned, progression to metaphase is a discontinuous process involving chromosome expansion as well as compaction. At late prophase, dependent on topoisomerase II and with concomitant cohesin release, chromosomes expand, axes split and straighten, and chromatin loops transit to a radial disposition around now-central axes. Finally, chromosomes globally compact, giving the metaphase state. These patterns are consistent with the hypothesis that the molecular events of chromosome morphogenesis are governed by accumulation and release of chromosome stress, created by chromatin compaction and expansion. Chromosome state could evolve analogously throughout the cell cycle. |*Metaphase [MESH] |*Mitosis [MESH] |Adenosine Triphosphatases/analysis [MESH] |Animals [MESH] |Cell Cycle Proteins/analysis [MESH] |Cell Line [MESH] |Chromosomal Proteins, Non-Histone/analysis [MESH] |Chromosomes, Mammalian/chemistry/*metabolism [MESH] |Cohesins [MESH] |DNA Topoisomerases, Type II/analysis [MESH] |DNA-Binding Proteins/analysis [MESH] |Deer [MESH] |HeLa Cells [MESH] |Humans [MESH] |Microscopy, Fluorescence [MESH] |Multiprotein Complexes/analysis [MESH]Chromosomes Progress to Metaphase in Multiple Discrete Steps via Globa(epmc).pdf DeepDyve Pubget Overpricing