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10.1101/cshperspect.a017145 http://scihub22266oqcxt.onion/10.1101/cshperspect.a017145 C4448705!4448705!26033081     free     free     free       Cold+Spring+Harb+Perspect+Med 2015 ; 5 (6): ä Nephropedia Template TP {{tp|p=26033081|t=2015. Genetic Modifiers and Oligogenic Inheritance |pdf=|usr=}}{{26033081}} gab.com Text Genetic Modifiers and Oligogenic Inheritance JO: Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=26033081 #FOAvip Despite remarkable progress in the identification of mutations that drive genetic disorders, progress in understanding the effect of genetic background on the penetrance and expressivity of causal alleles has been modest, in part because of the methodological challenges in identifying genetic modifiers. Nonetheless, the progressive discovery of modifier alleles has improved both our interpretative ability and our analytical tools to dissect such phenomena. In this review, we analyze the genetic properties and behaviors of modifiers as derived from studies in patient populations and model organisms and we highlight conceptual and technological tools used to overcome some of the challenges inherent in modifier mapping and cloning. Finally, we discuss how the identification of these modifiers has facilitated the elucidation of biological pathways and holds the potential to improve the clinical predictive value of primary causal mutations and to develop novel drug targets. Twit Text FOAVip Genetic Modifiers and Oligogenic Inheritance ????Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=26033081 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26033081 #FOAvip English Wikipedia <ref>{{Cite pmid|26033081}}</ref> Genetic Modifiers and Oligogenic Inheritance #MMPMID26033081 Kousi M; Katsanis N Cold Spring Harb Perspect Med 2015[Jun]; 5 (6): ä PMID26033081show ga Despite remarkable progress in the identification of mutations that drive genetic disorders, progress in understanding the effect of genetic background on the penetrance and expressivity of causal alleles has been modest, in part because of the methodological challenges in identifying genetic modifiers. Nonetheless, the progressive discovery of modifier alleles has improved both our interpretative ability and our analytical tools to dissect such phenomena. In this review, we analyze the genetic properties and behaviors of modifiers as derived from studies in patient populations and model organisms and we highlight conceptual and technological tools used to overcome some of the challenges inherent in modifier mapping and cloning. Finally, we discuss how the identification of these modifiers has facilitated the elucidation of biological pathways and holds the potential to improve the clinical predictive value of primary causal mutations and to develop novel drug targets. äGenetic Modifiers and Oligogenic Inheritance (epmc).pdf DeepDyve Pubget Overpricing