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10.1101/cshperspect.a018788

http://scihub22266oqcxt.onion/10.1101/cshperspect.a018788
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C4448613!4448613!26032717
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suck abstract from ncbi

pmid26032717      Cold+Spring+Harb+Perspect+Biol 2015 ; 7 (6): ä
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  • Signaling in Lymphocyte Activation #MMPMID26032717
  • Cantrell D
  • Cold Spring Harb Perspect Biol 2015[Jun]; 7 (6): ä PMID26032717show ga
  • The fate of T and B lymphocytes, the key cells that direct the adaptive immune response, is regulated by a diverse network of signal transduction pathways. The T- and B-cell antigen receptors are coupled to intracellular tyrosine kinases and adaptor molecules to control the metabolism of inositol phospholipids and calcium release. The production of inositol polyphosphates and lipid second messengers directs the activity of downstream guanine-nucleotide-binding proteins and protein and lipid kinases/phosphatases that control lymphocyte transcriptional and metabolic programs. Lymphocyte activation is modulated by costimulatory molecules and cytokines that elicit intracellular signaling that is integrated with the antigen-receptor-controlled pathways.
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