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10.1101/cshperspect.a015792 http://scihub22266oqcxt.onion/10.1101/cshperspect.a015792 C4448609!4448609!25722466     free     free     free       Cold+Spring+Harb+Perspect+Biol 2015 ; 7 (6): ä Nephropedia Template TP {{tp|p=25722466|t=2015. Chromosome Dynamics during Mitosis |pdf=|usr=}}{{25722466}} gab.com Text Chromosome Dynamics during Mitosis JO: Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=25722466 #FOAvip The primary goal of mitosis is to partition duplicated chromosomes into daughter cells. Eukaryotic chromosomes are equipped with two distinct classes of intrinsic machineries, cohesin and condensins, that ensure their faithful segregation during mitosis. Cohesin holds sister chromatids together immediately after their synthesis during S phase until the establishment of bipolar attachments to the mitotic spindle in metaphase. Condensins, on the other hand, attempt to ?resolve? sister chromatids by counteracting cohesin. The products of the balancing acts of cohesin and condensins are metaphase chromosomes, in which two rod-shaped chromatids are connected primarily at the centromere. In anaphase, this connection is released by the action of separase that proteolytically cleaves the remaining population of cohesin. Recent studies uncover how this series of events might be mechanistically coupled with each other and intricately regulated by a number of regulatory factors. Twit Text FOAVip Chromosome Dynamics during Mitosis ????Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=25722466 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25722466 #FOAvip English Wikipedia <ref>{{Cite pmid|25722466}}</ref> Chromosome Dynamics during Mitosis #MMPMID25722466 Hirano T Cold Spring Harb Perspect Biol 2015[Jun]; 7 (6): ä PMID25722466show ga The primary goal of mitosis is to partition duplicated chromosomes into daughter cells. Eukaryotic chromosomes are equipped with two distinct classes of intrinsic machineries, cohesin and condensins, that ensure their faithful segregation during mitosis. Cohesin holds sister chromatids together immediately after their synthesis during S phase until the establishment of bipolar attachments to the mitotic spindle in metaphase. Condensins, on the other hand, attempt to ?resolve? sister chromatids by counteracting cohesin. The products of the balancing acts of cohesin and condensins are metaphase chromosomes, in which two rod-shaped chromatids are connected primarily at the centromere. In anaphase, this connection is released by the action of separase that proteolytically cleaves the remaining population of cohesin. Recent studies uncover how this series of events might be mechanistically coupled with each other and intricately regulated by a number of regulatory factors. äChromosome Dynamics during Mitosis (epmc).pdf DeepDyve Pubget Overpricing