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10.1038/srep10627 http://scihub22266oqcxt.onion/10.1038/srep10627 C4448521!4448521 !26024305     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26024305 &cmd=llinks): Failed to open stream: HTTP request failed! 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A novel inhibitory mechanism of MRTF-A/B on the ICAM-1 gene expression in vascular endothelial cells |pdf=|usr=}}{{26024305 }} gab.com Text A novel inhibitory mechanism of MRTF-A/B on the ICAM-1 gene expression in vascular endothelial cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26024305 #FOAvip The roles of myocardin-related transcription factor A (MRTF-A) and MRTF-B in vascular endothelial cells are not completely understood. Here, we found a novel regulatory mechanism for MRTF-A/B function. MRTF-A/B tend to accumulate in the nucleus in arterial endothelial cells in vivo and human aortic endothelial cells (HAoECs) in vitro. In HAoECs, nuclear localization of MRTF-A/B was not significantly affected by Y27632 or latrunculin B, primarily due to the reduced binding of MRTF-A/B to G-actin and in part, to the low level of MRTF-A phosphorylation by ERK. MRTF-A/B downregulation by serum depletion or transfection of siRNA against MRTF-A and/or MRTF-B induced ICAM-1 expression in HAoECs. It is known that nuclear import of nuclear factor-?B (NF-?B) plays a key role in ICAM-1 gene transcription. However, nuclear accumulation of NF-?B p65 was not observed in MRTF-A/B-depleted HAoECs. Our present findings suggest that MRTF-A/B inhibit ICAM-1 mRNA expression by forming a complex with NF-?B p65 in the nucleus. Conversely, downregulation of MRTF-A/B alleviates this negative regulation without further translocation of NF-?B p65 into the nucleus. These results reveal the novel roles of MRTF-A/B in the homeostasis of vascular endothelium. Twit Text FOAVip A novel inhibitory mechanism of MRTF-A/B on the ICAM-1 gene expression in vascular endothelial cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26024305 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26024305 #FOAvip English Wikipedia <ref>{{Cite pmid|26024305 }}</ref> A novel inhibitory mechanism of MRTF-A/B on the ICAM-1 gene expression in vascular endothelial cells #MMPMID26024305 Hayashi K ; Murai T ; Oikawa H ; Masuda T ; Kimura K ; Muehlich S ; Prywes R ; Morita T Sci Rep 2015[May]; 5 (ä): 10627 PMID26024305 show ga The roles of myocardin-related transcription factor A (MRTF-A) and MRTF-B in vascular endothelial cells are not completely understood. Here, we found a novel regulatory mechanism for MRTF-A/B function. MRTF-A/B tend to accumulate in the nucleus in arterial endothelial cells in vivo and human aortic endothelial cells (HAoECs) in vitro. In HAoECs, nuclear localization of MRTF-A/B was not significantly affected by Y27632 or latrunculin B, primarily due to the reduced binding of MRTF-A/B to G-actin and in part, to the low level of MRTF-A phosphorylation by ERK. MRTF-A/B downregulation by serum depletion or transfection of siRNA against MRTF-A and/or MRTF-B induced ICAM-1 expression in HAoECs. It is known that nuclear import of nuclear factor-?B (NF-?B) plays a key role in ICAM-1 gene transcription. However, nuclear accumulation of NF-?B p65 was not observed in MRTF-A/B-depleted HAoECs. Our present findings suggest that MRTF-A/B inhibit ICAM-1 mRNA expression by forming a complex with NF-?B p65 in the nucleus. Conversely, downregulation of MRTF-A/B alleviates this negative regulation without further translocation of NF-?B p65 into the nucleus. These results reveal the novel roles of MRTF-A/B in the homeostasis of vascular endothelium. |*Gene Expression Regulation/drug effects [MESH] |Amides/pharmacology [MESH] |Animals [MESH] |Cell Communication [MESH] |Cell Line [MESH] |Cell Nucleus/metabolism [MESH] |Endothelial Cells/*metabolism [MESH] |Extracellular Signal-Regulated MAP Kinases/metabolism [MESH] |Humans [MESH] |Intercellular Adhesion Molecule-1/*genetics/metabolism [MESH] |Intracellular Space/metabolism [MESH] |Leukocytes/drug effects/metabolism [MESH] |Lipopolysaccharides/pharmacology [MESH] |Mice [MESH] |Models, Biological [MESH] |NF-kappa B/metabolism [MESH] |Protein Transport/drug effects [MESH] |Pyridines/pharmacology [MESH] |Trans-Activators/genetics/*metabolism [MESH] |Transcription Factors/genetics/*metabolism [MESH] |Transcription, Genetic [MESH]A novel inhibitory mechanism of MRTF-A/B on the ICAM-1 gene expression(epmc).pdf DeepDyve Pubget Overpricing