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10.3389/fcell.2015.00033

http://scihub22266oqcxt.onion/10.3389/fcell.2015.00033
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C4448519!4448519!26075202
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suck abstract from ncbi


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pmid26075202      Front+Cell+Dev+Biol 2015 ; 3 (ä): ä
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  • A top-down view of the tumor microenvironment: structure, cells and signaling #MMPMID26075202
  • Bhome R; Bullock MD; Al Saihati HA; Goh RW; Primrose JN; Sayan AE; Mirnezami AH
  • Front Cell Dev Biol 2015[]; 3 (ä): ä PMID26075202show ga
  • It is well established that the tumor microenvironment (TME) contributes to cancer progression. Stromal cells can be divided into mesenchymal, vascular, and immune. Signaling molecules secreted by the tumor corrupts these cells to create ?activated? stroma. Equally, the extracellular matrix (ECM) contributes to tumor development and invasion by forming a biologically active scaffold. In this review we describe the key structural, cellular and signaling components of the TME with a perspective on stromal soluble factors and microRNAs (miRNAs).
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