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Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Front+Cell+Dev+Biol 2015 ; 3 (ä): ä Nephropedia Template TP
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A top-down view of the tumor microenvironment: structure, cells and signaling #MMPMID26075202
Front Cell Dev Biol 2015[]; 3 (ä): ä PMID26075202show ga
It is well established that the tumor microenvironment (TME) contributes to cancer progression. Stromal cells can be divided into mesenchymal, vascular, and immune. Signaling molecules secreted by the tumor corrupts these cells to create ?activated? stroma. Equally, the extracellular matrix (ECM) contributes to tumor development and invasion by forming a biologically active scaffold. In this review we describe the key structural, cellular and signaling components of the TME with a perspective on stromal soluble factors and microRNAs (miRNAs).