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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Transl+Res
2015 ; 7
(3
): 598-606
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BOLD-MRI evaluation of subcutaneous and visceral adipose tissue oxygenation
status: effect of dietary salt intake
#MMPMID26045898
Yuan F
; Guo ZZ
; Ji WJ
; Ma YQ
; Zhang Z
; Zhou X
; Li YM
Am J Transl Res
2015[]; 7
(3
): 598-606
PMID26045898
show ga
To investigate the feasibility of blood oxygen level dependent magnetic resonance
imaging (BOLD-MRI) in evaluating human subcutaneous and visceral adipose tissue
(AT) oxygenation status, as well as their responses to dietary salt
loading/depletion, we enrolled 16 healthy subjects [mean body mass index (BMI):
24.8 ± 2.7 kg/m(2)] to conduct a dietary intervention study, beginning with a
3-day run-in period for usual diet, followed by a 7-day high-salt diet (? 15 g
NaCl/day) and a 7-day low-salt diet (? 5 g NaCl/day). Abdominal BOLD-MRI scan was
performed to evaluate oxygenation in waist subcutaneous and perirenal (visceral)
AT. Two subjects with lower BMI were excluded because of the difficulty to
identify subcutaneous AT. High salt diet led to a consistent increase in R2*
signal (a parameter for increased hypoxia) both in subcutaneous and visceral AT
(all P < 0.0001), which was completely regressed to baseline levels by low salt
diet. In addition, subcutaneous AT R2* values at any time points, were all higher
than that of visceral AT (all P < 0.0001). Pearson correlation analysis revealed
that the visceral AT R2* levels were negatively associated obesity indicators
(waist circumference, waist-to-hip ratio and BMI). On the contrary, although a
trend towards negative associations between the subcutaneous AT R2* and obesity
indicators was observed, none of the associations reached statistical
significances. Thus, our data demonstrate the possibility of simultaneous
detection of human subcutaneous and visceral AT oxygenation status using
BOLD-MRI. In addition, there is a more close relationship visceral AT oxygenation
status and the development of obesity.