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10.3390/toxins7051821 http://scihub22266oqcxt.onion/10.3390/toxins7051821 C4448176!4448176!26008236     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxins+(Basel) 2015 ; 7 (5): 1821-36 Nephropedia Template TP {{tp|p=26008236|t=2015. Superantigens Modulate Bacterial Density during Staphylococcus aureus Nasal Colonization |pdf=|usr=}}{{26008236}} gab.com Text Superantigens Modulate Bacterial Density during Staphylococcus aureus Nasal Colonization JO: Toxins (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=26008236 #FOAvip Superantigens (SAgs) are potent microbial toxins that function to activate large numbers of T cells in a T cell receptor (TCR) V?-specific manner, resulting in excessive immune system activation. Staphylococcus aureus possesses a large repertoire of distinct SAgs, and in the context of host-pathogen interactions, staphylococcal SAg research has focused primarily on the role of these toxins in severe and invasive diseases. However, the contribution of SAgs to colonization by S. aureus remains unclear. We developed a two-week nasal colonization model using SAg-sensitive transgenic mice expressing HLA-DR4, and evaluated the role of SAgs using two well-studied stains of S. aureus. S. aureus Newman produces relatively low levels of staphylococcal enterotoxin A (SEA), and although we did not detect significant TCR-V? specific changes during wild-type S. aureus Newman colonization, S. aureus Newman ?sea established transiently higher bacterial loads in the nose. S. aureus COL produces relatively high levels of staphylococcal enterotoxin B (SEB), and colonization with wild-type S. aureus COL resulted in clear V?8-specific T cell skewing responses. S. aureus COL ?seb established consistently higher bacterial loads in the nose. These data suggest that staphylococcal SAgs may be involved in regulating bacterial densities during nasal colonization. Twit Text FOAVip Superantigens Modulate Bacterial Density during Staphylococcus aureus Nasal Colonization ????Toxins (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=26008236 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26008236 #FOAvip English Wikipedia <ref>{{Cite pmid|26008236}}</ref> Superantigens Modulate Bacterial Density during Staphylococcus aureus Nasal Colonization #MMPMID26008236 Xu SX; Kasper KJ; Zeppa JJ; McCormick JK Toxins (Basel) 2015[May]; 7 (5): 1821-36 PMID26008236show ga Superantigens (SAgs) are potent microbial toxins that function to activate large numbers of T cells in a T cell receptor (TCR) V?-specific manner, resulting in excessive immune system activation. Staphylococcus aureus possesses a large repertoire of distinct SAgs, and in the context of host-pathogen interactions, staphylococcal SAg research has focused primarily on the role of these toxins in severe and invasive diseases. However, the contribution of SAgs to colonization by S. aureus remains unclear. We developed a two-week nasal colonization model using SAg-sensitive transgenic mice expressing HLA-DR4, and evaluated the role of SAgs using two well-studied stains of S. aureus. S. aureus Newman produces relatively low levels of staphylococcal enterotoxin A (SEA), and although we did not detect significant TCR-V? specific changes during wild-type S. aureus Newman colonization, S. aureus Newman ?sea established transiently higher bacterial loads in the nose. S. aureus COL produces relatively high levels of staphylococcal enterotoxin B (SEB), and colonization with wild-type S. aureus COL resulted in clear V?8-specific T cell skewing responses. S. aureus COL ?seb established consistently higher bacterial loads in the nose. These data suggest that staphylococcal SAgs may be involved in regulating bacterial densities during nasal colonization. äSuperantigens Modulate Bacterial Density during Staphylococcus aureus (epmc).pdf DeepDyve Pubget Overpricing