Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3390/toxins7051702 http://scihub22266oqcxt.onion/10.3390/toxins7051702 C4448169!4448169!26008232     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxins+(Basel) 2015 ; 7 (5): 1702-21 Nephropedia Template TP {{tp|p=26008232|t=2015. Perfringolysin O: The Underrated Clostridium perfringens Toxin?|pdf=|usr=}}{{26008232}} gab.com Text Perfringolysin O: The Underrated Clostridium perfringens Toxin JO: Toxins (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=26008232 #FOAvip The anaerobic bacterium Clostridium perfringens expresses multiple toxins that promote disease development in both humans and animals. One such toxin is perfringolysin O (PFO, classically referred to as ? toxin), a pore-forming cholesterol-dependent cytolysin (CDC). PFO is secreted as a water-soluble monomer that recognizes and binds membranes via cholesterol. Membrane-bound monomers undergo structural changes that culminate in the formation of an oligomerized prepore complex on the membrane surface. The prepore then undergoes conversion into the bilayer-spanning pore measuring approximately 250?300 Å in diameter. PFO is expressed in nearly all identified C. perfringens strains and harbors interesting traits that suggest a potential undefined role for PFO in disease development. Research has demonstrated a role for PFO in gas gangrene progression and bovine necrohemorrhagic enteritis, but there is limited data available to determine if PFO also functions in additional disease presentations caused by C. perfringens. This review summarizes the known structural and functional characteristics of PFO, while highlighting recent insights into the potential contributions of PFO to disease pathogenesis. Twit Text FOAVip Perfringolysin O: The Underrated Clostridium perfringens Toxin ????Toxins (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=26008232 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26008232 #FOAvip English Wikipedia <ref>{{Cite pmid|26008232}}</ref> Perfringolysin O: The Underrated Clostridium perfringens Toxin? #MMPMID26008232 Verherstraeten S; Goossens E; Valgaeren B; Pardon B; Timbermont L; Haesebrouck F; Ducatelle R; Deprez P; Wade KR; Tweten R; Van Immerseel F Toxins (Basel) 2015[May]; 7 (5): 1702-21 PMID26008232show ga The anaerobic bacterium Clostridium perfringens expresses multiple toxins that promote disease development in both humans and animals. One such toxin is perfringolysin O (PFO, classically referred to as ? toxin), a pore-forming cholesterol-dependent cytolysin (CDC). PFO is secreted as a water-soluble monomer that recognizes and binds membranes via cholesterol. Membrane-bound monomers undergo structural changes that culminate in the formation of an oligomerized prepore complex on the membrane surface. The prepore then undergoes conversion into the bilayer-spanning pore measuring approximately 250?300 Å in diameter. PFO is expressed in nearly all identified C. perfringens strains and harbors interesting traits that suggest a potential undefined role for PFO in disease development. Research has demonstrated a role for PFO in gas gangrene progression and bovine necrohemorrhagic enteritis, but there is limited data available to determine if PFO also functions in additional disease presentations caused by C. perfringens. This review summarizes the known structural and functional characteristics of PFO, while highlighting recent insights into the potential contributions of PFO to disease pathogenesis. äPerfringolysin O: The Underrated Clostridium perfringens Toxin?(epmc).pdf DeepDyve Pubget Overpricing