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10.1016/j.immuni.2015.04.013 http://scihub22266oqcxt.onion/10.1016/j.immuni.2015.04.013 C4448150!4448150!25992860     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2015 ; 42 (5): 864-76 Nephropedia Template TP {{tp|p=25992860|t=2015. Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse |pdf=|usr=}}{{25992860}} gab.com Text Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25992860 #FOAvip Cytotoxic T lymphocytes (CTLs) use polarized secretion to rapidly destroy virally infected and tumor cells. To understand the temporal relationships between key events leading to secretion, we used high-resolution 4D imaging. CTLs approached targets with actin-rich projections at the leading edge, creating an initially actin-enriched contact with rearward-flowing actin. Within 1 min, cortical actin reduced across the synapse, T cell receptors (TCRs) clustered centrally to form the central supramolecular activation cluster (cSMAC), and centrosome polarization began. Granules clustered around the moving centrosome within 2.5 min and reached the synapse after 6 min. TCR-bearing intracellular vesicles were delivered to the cSMAC as the centrosome docked. We found that the centrosome and granules were delivered to an area of membrane with reduced cortical actin density and phospholipid PIP2. These data resolve the temporal order of events during synapse maturation in 4D and reveal a critical role for actin depletion in regulating secretion. Twit Text FOAVip Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25992860 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25992860 #FOAvip English Wikipedia <ref>{{Cite pmid|25992860}}</ref> Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse #MMPMID25992860 Ritter A; Asano Y; Stinchcombe J; Dieckmann N; Chen BC; Gawden-Bone C; van Engelenburg S; Legant W; Gao L; Davidson M; Betzig E; Lippincott-Schwartz J; Griffiths G Immunity 2015[May]; 42 (5): 864-76 PMID25992860show ga Cytotoxic T lymphocytes (CTLs) use polarized secretion to rapidly destroy virally infected and tumor cells. To understand the temporal relationships between key events leading to secretion, we used high-resolution 4D imaging. CTLs approached targets with actin-rich projections at the leading edge, creating an initially actin-enriched contact with rearward-flowing actin. Within 1 min, cortical actin reduced across the synapse, T cell receptors (TCRs) clustered centrally to form the central supramolecular activation cluster (cSMAC), and centrosome polarization began. Granules clustered around the moving centrosome within 2.5 min and reached the synapse after 6 min. TCR-bearing intracellular vesicles were delivered to the cSMAC as the centrosome docked. We found that the centrosome and granules were delivered to an area of membrane with reduced cortical actin density and phospholipid PIP2. These data resolve the temporal order of events during synapse maturation in 4D and reveal a critical role for actin depletion in regulating secretion. äActin Depletion Initiates Events Leading to Granule Secretion at the I(epmc).pdf DeepDyve Pubget Overpricing