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Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Immunity 2015 ; 42 (5): 903-15 Nephropedia Template TP
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Integrin ?v?8-Mediated TGF-? Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation #MMPMID25979421
Worthington J; Kelly A; Smedley C; Bauché D; Campbell S; Marie J; Travis M
Immunity 2015[May]; 42 (5): 903-15 PMID25979421show ga
Regulatory T (Treg) cells play a pivotal role in suppressing self-harmful T cell responses, but how Treg cells mediate suppression to maintain immune homeostasis and limit responses during inflammation is unclear. Here we show that effector Treg cells express high amounts of the integrin ?v?8, which enables them to activate latent transforming growth factor-? (TGF-?). Treg-cell-specific deletion of integrin ?v?8 did not result in a spontaneous inflammatory phenotype, suggesting that this pathway is not important in Treg-cell-mediated maintenance of immune homeostasis. However, Treg cells lacking expression of integrin ?v?8 were unable to suppress pathogenic T cell responses during active inflammation. Thus, our results identify a mechanism by which Treg cells suppress exuberant immune responses, highlighting a key role for effector Treg-cell-mediated activation of latent TGF-? in suppression of self-harmful T cell responses during active inflammation.