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10.1016/j.immuni.2015.04.012 http://scihub22266oqcxt.onion/10.1016/j.immuni.2015.04.012 C4448149!4448149 !25979421     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25979421 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunity 2015 ; 42 (5 ): 903-15 Nephropedia Template TP {{tp|p=25979421 |t=2015. Integrin ?v?8-Mediated TGF-? Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation |pdf=|usr=}}{{25979421 }} gab.com Text Integrin v 8-Mediated TGF- Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25979421 #FOAvip Regulatory T (Treg) cells play a pivotal role in suppressing self-harmful T cell responses, but how Treg cells mediate suppression to maintain immune homeostasis and limit responses during inflammation is unclear. Here we show that effector Treg cells express high amounts of the integrin ?v?8, which enables them to activate latent transforming growth factor-? (TGF-?). Treg-cell-specific deletion of integrin ?v?8 did not result in a spontaneous inflammatory phenotype, suggesting that this pathway is not important in Treg-cell-mediated maintenance of immune homeostasis. However, Treg cells lacking expression of integrin ?v?8 were unable to suppress pathogenic T cell responses during active inflammation. Thus, our results identify a mechanism by which Treg cells suppress exuberant immune responses, highlighting a key role for effector Treg-cell-mediated activation of latent TGF-? in suppression of self-harmful T cell responses during active inflammation. Twit Text FOAVip Integrin v 8-Mediated TGF- Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25979421 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25979421 #FOAvip English Wikipedia <ref>{{Cite pmid|25979421 }}</ref> Integrin ?v?8-Mediated TGF-? Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation #MMPMID25979421 Worthington JJ ; Kelly A ; Smedley C ; Bauché D ; Campbell S ; Marie JC ; Travis MA Immunity 2015[May]; 42 (5 ): 903-15 PMID25979421 show ga Regulatory T (Treg) cells play a pivotal role in suppressing self-harmful T cell responses, but how Treg cells mediate suppression to maintain immune homeostasis and limit responses during inflammation is unclear. Here we show that effector Treg cells express high amounts of the integrin ?v?8, which enables them to activate latent transforming growth factor-? (TGF-?). Treg-cell-specific deletion of integrin ?v?8 did not result in a spontaneous inflammatory phenotype, suggesting that this pathway is not important in Treg-cell-mediated maintenance of immune homeostasis. However, Treg cells lacking expression of integrin ?v?8 were unable to suppress pathogenic T cell responses during active inflammation. Thus, our results identify a mechanism by which Treg cells suppress exuberant immune responses, highlighting a key role for effector Treg-cell-mediated activation of latent TGF-? in suppression of self-harmful T cell responses during active inflammation. |Animals [MESH] |Cell Proliferation [MESH] |Colitis/immunology [MESH] |Disease Models, Animal [MESH] |Gene Expression Regulation/immunology [MESH] |Humans [MESH] |Inflammation Mediators/immunology [MESH] |Inflammation/*immunology [MESH] |Integrins/genetics/*metabolism [MESH] |Mice [MESH] |Models, Immunological [MESH] |T-Lymphocytes, Regulatory/cytology/*immunology [MESH]Integrin ?v?8-Mediated TGF-? Activation by Effector Regulatory T Cells(epmc).pdf DeepDyve Pubget Overpricing