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10.1016/j.cell.2015.04.042 http://scihub22266oqcxt.onion/10.1016/j.cell.2015.04.042 C4448148!4448148!26000481     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2015 ; 161 (5): 1046-57 Nephropedia Template TP {{tp|p=26000481|t=2015. In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior |pdf=|usr=}}{{26000481}} gab.com Text In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=26000481 #FOAvip Most cancer cells release heterogeneous populations of extracellular vesicles (EVs) containing proteins, lipids, and nucleic acids. In vitro experiments showed that EV uptake can lead to transfer of functional mRNA and altered cellular behavior. However, similar in vivo experiments remain challenging because cells that take up EVs cannot be discriminated from non-EV-receiving cells. Here, we used the Cre-LoxP system to directly identify tumor cells that take up EVs in vivo. We show that EVs released by malignant tumor cells are taken up by less malignant tumor cells located within the same and within distant tumors and that these EVs carry mRNAs involved in migration and metastasis. By intravital imaging, we show that the less malignant tumor cells that take up EVs display enhanced migratory behavior and metastatic capacity. We postulate that tumor cells locally and systemically share molecules carried by EVs in vivo and that this affects cellular behavior. Twit Text FOAVip In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=26000481 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26000481 #FOAvip English Wikipedia <ref>{{Cite pmid|26000481}}</ref> In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior #MMPMID26000481 Zomer A; Maynard C; Verweij F; Kamermans A; Schäfer R; Beerling E; Schiffelers R; de Wit E; Berenguer J; Ellenbroek S; Wurdinger T; Pegtel D; van Rheenen J Cell 2015[May]; 161 (5): 1046-57 PMID26000481show ga Most cancer cells release heterogeneous populations of extracellular vesicles (EVs) containing proteins, lipids, and nucleic acids. In vitro experiments showed that EV uptake can lead to transfer of functional mRNA and altered cellular behavior. However, similar in vivo experiments remain challenging because cells that take up EVs cannot be discriminated from non-EV-receiving cells. Here, we used the Cre-LoxP system to directly identify tumor cells that take up EVs in vivo. We show that EVs released by malignant tumor cells are taken up by less malignant tumor cells located within the same and within distant tumors and that these EVs carry mRNAs involved in migration and metastasis. By intravital imaging, we show that the less malignant tumor cells that take up EVs display enhanced migratory behavior and metastatic capacity. We postulate that tumor cells locally and systemically share molecules carried by EVs in vivo and that this affects cellular behavior. äIn Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of(epmc).pdf DeepDyve Pubget Overpricing