Vacuolar ATPase in Phagosome-Lysosome Fusion #MMPMID25903133
Kissing S; Hermsen C; Repnik U; Nesset CK; von Bargen K; Griffiths G; Ichihara A; Lee BS; Schwake M; De Brabander J; Haas A; Saftig P
J Biol Chem 2015[May]; 290 (22): 14166-80 PMID25903133show ga
Background: The vacuolar H+-ATPase complex is thought to contribute to membrane fusion.Results: v-ATPase complex knock-out experiments in mice revealed that its absence does not affect phagosome-lysosome fusion.Conclusion: Participation of v-ATPase in phagosome-lysosome fusion is unlikely.Significance: Fusion between lysosomes/late endosomes and phagosomes is not controlled by the v-ATPase.