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Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Biol+Chem 2015 ; 290 (22): 14120-9 Nephropedia Template TP
J Biol Chem 2015[May]; 290 (22): 14120-9 PMID25897075show ga
Background: Posttranslational regulation of rictor, a key partner of mTOR complex 2, and its underlying mechanism are largely undefined and thus are the focus of this study.Results: FBXW7 interacts with rictor and mediates its degradation; this process requires phosphorylation of rictor at threonine 1695 by GSK3.Conclusion: Rictor undergoes GSK3-dependent, FBXW7-mediated ubiquitination and proteasomal degradation.Significance: A previously unknown mechanism underlying posttranslational regulation of rictor expression is suggested.