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10.1074/jbc.M114.628818

http://scihub22266oqcxt.onion/10.1074/jbc.M114.628818
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C4447973!4447973!25864198
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suck abstract from ncbi


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pmid25864198      J+Biol+Chem 2015 ; 290 (22): 14004-18
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  • WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling* #MMPMID25864198
  • Maeda A; Ono M; Holmbeck K; Li L; Kilts TM; Kram V; Noonan ML; Yoshioka Y; McNerny EMB; Tantillo MA; Kohn DH; Lyons KM; Robey PG; Young MF
  • J Biol Chem 2015[May]; 290 (22): 14004-18 PMID25864198show ga
  • Background: WISP1 is expressed in bone, but its roles in osteogenesis are unclear.Results: WISP1 regulates bone mineral content, cortical and trabecular bone thickness, and bone strength during aging by modulating osteoblast and osteoclast function and Wnt signaling.Conclusion: WISP1 controls bone integrity by regulating bone turnover.Significance: WISP1 is a novel target for modulating bone turnover and improving bone strength.
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