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10.1074/jbc.M114.634535

http://scihub22266oqcxt.onion/10.1074/jbc.M114.634535
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C4447969!4447969!25882842
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suck abstract from ncbi


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pmid25882842      J+Biol+Chem 2015 ; 290 (22): 13958-71
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  • CRL3IBTK Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation* #MMPMID25882842
  • Pisano A; Ceglia S; Palmieri C; Vecchio E; Fiume G; de Laurentiis A; Mimmi S; Falcone C; Iaccino E; Scialdone A; Pontoriero M; Masci FF; Valea R; Krishnan S; Gaspari M; Cuda G; Scala G; Quinto I
  • J Biol Chem 2015[May]; 290 (22): 13958-71 PMID25882842show ga
  • Background: IBtk? is an uncharacterized protein belonging to the family of BTB proteins.Results: IBtk? is the substrate receptor for a Cullin3-dependent ubiquitin ligase promoting ubiquitylation and proteasomal degradation of Pdcd4.Conclusion: By regulating Pdcd4 stability, IBtk? can modulate the translation of specific mRNAs under different cellular conditions.Significance: The identification of new players in the ubiquitin/proteasome pathways contributes to a better understanding of protein homeostasis.
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