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10.1186/2193-1801-3-721 http://scihub22266oqcxt.onion/10.1186/2193-1801-3-721 C4447768!4447768!26034695     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Springerplus 2014 ; 3 (ä): ä Nephropedia Template TP {{tp|p=26034695|t=2014. Clinicopathologic characteristics of SALL4-immunopositive hepatocellular carcinoma |pdf=|usr=}}{{26034695}} gab.com Text Clinicopathologic characteristics of SALL4-immunopositive hepatocellular carcinoma JO: Springerplus http://www.kidney.de/pget.php?&tw=1&pmid=26034695 #FOAvip The aim of this study was to investigate the clinicopathologic characteristics of sal-like protein 4 (SALL4)-immunopositive hepatocellular carcinoma (HCC). Solitary HCCs that were surgically treated at the University of Tokyo Hospital between 2000 and 2008 were the subject of this study. Diffuse, non-punctate nuclear immunoreactivity to SALL4 was observed in 47 of 337 HCCs (13.9%). Compared to patients with SALL4-negative HCC, patients with SALL4-positive HCC were younger (mean 59.2 years vs. 65.2 years), more frequently female (44.7% vs. 18.3%) and positive for hepatitis B virus angigen (42.6% vs. 18.6%). They had much higher serum levels of alpha-fetoprotein (median 3976.5 ng/ml vs. 14.0 ng/ml) (P?<?0.001). Liver function tended to be favourable, as was shown by less indocyanine green retention at 15 minutes (ICG15), in patients with SALL4-positive HCCs (P?<?0.001). Histologically, SALL4-positive HCCs exhibited less histological differentiation (P?<?0.001) and had a higher frequency of micro- or macrovascular invasion (72.3% vs. 54.1%, P?=?0.019) and intrahepatic metastasis (34.0% vs. 19.3%, P?=?0.022) than SALL4-negative HCCs. SALL4-positive HCCs were more frequently immunoreactive for cytokeratin 19 (42.6% vs. 11.7%, P?<?0.001) and EpCAM (51.1% vs. 8.3%, P?<?0.001). The log-rank test indicated short-term disease-free survival (< 1 year) of patients with SALL4-positive HCC was worse than those with SALL4-negative HCC (P?=?0.019). Multivariate analyses, however, failed to show the prognostic significance of SALL4 immunoreactivity in HCCs. In conclusion, SALL4-immunopositive HCCs constitute a subset with characteristic patient backgrounds and somewhat aggressive behavior, as was manifested by frequent vascular invasion and intrahepatic metastasis. There was little prognostic significance of SALL4 immunoreactivity in HCCs. Twit Text FOAVip Clinicopathologic characteristics of SALL4-immunopositive hepatocellular carcinoma ????Springerplus http://www.kidney.de/pget.php?&tw=1&pmid=26034695 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26034695 #FOAvip English Wikipedia <ref>{{Cite pmid|26034695}}</ref> Clinicopathologic characteristics of SALL4-immunopositive hepatocellular carcinoma #MMPMID26034695 Shibahara J; Ando S; Hayashi A; Sakamoto Y; Hesegawa K; Kokudo N; Fukayama M Springerplus 2014[]; 3 (ä): ä PMID26034695show ga The aim of this study was to investigate the clinicopathologic characteristics of sal-like protein 4 (SALL4)-immunopositive hepatocellular carcinoma (HCC). Solitary HCCs that were surgically treated at the University of Tokyo Hospital between 2000 and 2008 were the subject of this study. Diffuse, non-punctate nuclear immunoreactivity to SALL4 was observed in 47 of 337 HCCs (13.9%). Compared to patients with SALL4-negative HCC, patients with SALL4-positive HCC were younger (mean 59.2 years vs. 65.2 years), more frequently female (44.7% vs. 18.3%) and positive for hepatitis B virus angigen (42.6% vs. 18.6%). They had much higher serum levels of alpha-fetoprotein (median 3976.5 ng/ml vs. 14.0 ng/ml) (P? äClinicopathologic characteristics of SALL4-immunopositive hepatocellul(epmc).pdf DeepDyve Pubget Overpricing