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10.1186/2193-1801-3-293 http://scihub22266oqcxt.onion/10.1186/2193-1801-3-293 C4447724!4447724!26034661     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Springerplus 2014 ; 3 (ä): ä Nephropedia Template TP {{tp|p=26034661|t=2014. A systematic review of gemcitabine and taxanes combination therapy randomized trials for metastatic breast cancer |pdf=|usr=}}{{26034661}} gab.com Text A systematic review of gemcitabine and taxanes combination therapy randomized trials for metastatic breast cancer JO: Springerplus http://www.kidney.de/pget.php?&tw=1&pmid=26034661 #FOAvip Purpose: Gemcitabine/taxanes-based combination shows anti-tumor activity for the treatment of metastatic breast cancer, but there is a debate regarding the advantages of gemcitabine and taxanes regimens as a first-line or second-line treatment for metastatic breast cancer. Here we conducted a systematic review and meta-analysis to compare the efficacy and toxicity for patients receiving chemotherapy with or without GT-based regimens. Methods: The randomized controlled trials were performed by searching Pubmed, MEDLINE, EMBASE, and conference proceedings. We identified eight randomized controlled trials and then extracted and combined the data using to calculate hazard ratios (HR). The primary outcomes were progression-free survival (PFS) and time to progression (TTP). The secondary outcomes were overall survival (OS) and acute toxicity. A meta-analysis was performed using Review Manager Version 4.2. Results: Eight eligible trails were identified. These studies involved 2234 patients with metastatic breast cancer, (1122 patients received GT-based combination regimen and 1112 patients received a regimen without the combination). A fixed-effects model meta-analysis showed that ORR and TTP are superior for GT-treated patients ORR (OR?=?1.28, 95% CI 1.07-1.53), TTP (HR?=?0.80; 95% CI 0.71-0.89). And GT-based combination significantly improved OS in the first-line subgroup (HR?=?0.84; 95% CI 0.71-0.99). However, there were significant differences regarding acute hematological toxicity, particularly thrombocytopenia. Conclusion: Gemcitabine/taxanes-treated patients with metastatic breast cancer showed a significant improvement in the ORR, TTP and OS (first-line background) compared to patients not treated with the combination regimen. Twit Text FOAVip A systematic review of gemcitabine and taxanes combination therapy randomized trials for metastatic breast cancer ????Springerplus http://www.kidney.de/pget.php?&tw=1&pmid=26034661 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26034661 #FOAvip English Wikipedia <ref>{{Cite pmid|26034661}}</ref> A systematic review of gemcitabine and taxanes combination therapy randomized trials for metastatic breast cancer #MMPMID26034661 Hu Q; Jiang Jx; Luo L; Yang X; Lin X; Dinglin Xx; Zhang W; Wu Jy; Yao Hr Springerplus 2014[]; 3 (ä): ä PMID26034661show ga Purpose: Gemcitabine/taxanes-based combination shows anti-tumor activity for the treatment of metastatic breast cancer, but there is a debate regarding the advantages of gemcitabine and taxanes regimens as a first-line or second-line treatment for metastatic breast cancer. Here we conducted a systematic review and meta-analysis to compare the efficacy and toxicity for patients receiving chemotherapy with or without GT-based regimens. Methods: The randomized controlled trials were performed by searching Pubmed, MEDLINE, EMBASE, and conference proceedings. We identified eight randomized controlled trials and then extracted and combined the data using to calculate hazard ratios (HR). The primary outcomes were progression-free survival (PFS) and time to progression (TTP). The secondary outcomes were overall survival (OS) and acute toxicity. A meta-analysis was performed using Review Manager Version 4.2. Results: Eight eligible trails were identified. These studies involved 2234 patients with metastatic breast cancer, (1122 patients received GT-based combination regimen and 1112 patients received a regimen without the combination). A fixed-effects model meta-analysis showed that ORR and TTP are superior for GT-treated patients ORR (OR?=?1.28, 95% CI 1.07-1.53), TTP (HR?=?0.80; 95% CI 0.71-0.89). And GT-based combination significantly improved OS in the first-line subgroup (HR?=?0.84; 95% CI 0.71-0.99). However, there were significant differences regarding acute hematological toxicity, particularly thrombocytopenia. Conclusion: Gemcitabine/taxanes-treated patients with metastatic breast cancer showed a significant improvement in the ORR, TTP and OS (first-line background) compared to patients not treated with the combination regimen. äA systematic review of gemcitabine and taxanes combination therapy ran(epmc).pdf DeepDyve Pubget Overpricing