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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Cardiovasc+Electrophysiol
2014 ; 25
(10
): 1115-8
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gab.com Text
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English Wikipedia
Transvenous stimulation of the renal sympathetic nerves increases systemic blood
pressure: a potential new treatment option for neurocardiogenic syncope
#MMPMID24902981
Madhavan M
; Desimone CV
; Ebrille E
; Mulpuru SK
; Mikell SB
; Johnson SB
; Suddendorf SH
; Ladewig DJ
; Gilles EJ
; Danielsen AJ
; Asirvatham SJ
J Cardiovasc Electrophysiol
2014[Oct]; 25
(10
): 1115-8
PMID24902981
show ga
BACKGROUND: Neurocardiogenic syncope (NCS) is a common and sometimes debilitating
disorder, with no consistently effective treatment. NCS is due to a combination
of bradycardia and vasodilation leading to syncope. Although pacemaker devices
have been tried in treating the bradycardic aspect of NCS, no device-based
therapy exists to treat the coexistent vasodilation that occurs. The renal
sympathetic innervation has been the target of denervation to treat hypertension.
We hypothesized that stimulation of the renal sympathetic nerves can increase
blood pressure and counteract vasodilation in NCS. METHODS AND RESULTS:
High-frequency stimulation (800-900 pps, 10 V, 30-200 seconds) was performed
using a quadripolar catheter in the renal vein of 7 dogs and 1 baboon. A
significant increase in blood pressure (BP; mean [SD] systolic BP 117 [±28] vs.
128 [±33], diastolic BP 75 [±19] vs. 87 [±29] mmHg) was noted during the
stimulation, which returned to baseline after cessation of stimulation. The mean
increase in systolic and diastolic BP was 13.0 (±3.3) (P = 0.006) and 10.2 (±4.6)
(P = 0.08), respectively. CONCLUSION: We report the first ever study of
feasibility and safety of high-frequency electrical stimulation of the renal
sympathetic innervation to increase BP in animal models. This has potential
applications in the treatment of hypotensive states such as NCS.