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10.1210/me.2015-1062 http://scihub22266oqcxt.onion/10.1210/me.2015-1062 C4447638!4447638 !25866875     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25866875 &cmd=llinks): Failed to open stream: HTTP request failed! 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Minireview: From the bench, toward the clinic: therapeutic opportunities for cannabinoid receptor modulation |pdf=|usr=}}{{25866875 }} gab.com Text Minireview: From the bench, toward the clinic: therapeutic opportunities for cannabinoid receptor modulation JO: Mol Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=25866875 #FOAvip The effects of cannabinoids have been known for centuries and over the past several decades two G protein-coupled receptors, CB1 and CB2, that are responsible for their activity have been identified. Endogenous lipid-derived cannabinergic agents have been found, biosynthetic and catabolic machinery has been characterized, and synthetic agents have been designed to modulate these receptors. Selective agents including agonists, antagonists, inverse agonists, and novel allosteric modulators targeting either CB1 or CB2 have been developed to inhibit or augment their basal tone. As a result, the role these receptors play in human physiology and their potential therapeutic applications in disease states are being elucidated. The CB1 receptor, although ubiquitous, is densely expressed in the brain, and CB2 is largely found on cells of immune origin. This minireview highlights the role of CB1 in excitotoxic assaults in the brain and its potential to limit addiction liability. In addition, it will examine the relationship between receptor activity and stimulation of insulin release from pancreatic ?-cells, insulin resistance, and feeding behavior leading toward obesity. The roles of CB2 in the neuropathology of amyotrophic lateral sclerosis and in the central manifestations of chronic HIV infection potentially converge at inflammatory cell activation, thereby providing an opportunity for intervention. Last, CB2 modulation is discussed in the context of an experimental model of postmenopausal osteoporosis. Achieving exquisite receptor selectivity and elucidating the mechanisms underlying receptor inhibition and activation will be essential for the development of the next generation of cannabinergic-based therapeutic agents. Twit Text FOAVip Minireview: From the bench, toward the clinic: therapeutic opportunities for cannabinoid receptor modulation ????Mol Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=25866875 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25866875 #FOAvip English Wikipedia <ref>{{Cite pmid|25866875 }}</ref> Minireview: From the bench, toward the clinic: therapeutic opportunities for cannabinoid receptor modulation #MMPMID25866875 Picone RP ; Kendall DA Mol Endocrinol 2015[Jun]; 29 (6 ): 801-13 PMID25866875 show ga The effects of cannabinoids have been known for centuries and over the past several decades two G protein-coupled receptors, CB1 and CB2, that are responsible for their activity have been identified. Endogenous lipid-derived cannabinergic agents have been found, biosynthetic and catabolic machinery has been characterized, and synthetic agents have been designed to modulate these receptors. Selective agents including agonists, antagonists, inverse agonists, and novel allosteric modulators targeting either CB1 or CB2 have been developed to inhibit or augment their basal tone. As a result, the role these receptors play in human physiology and their potential therapeutic applications in disease states are being elucidated. The CB1 receptor, although ubiquitous, is densely expressed in the brain, and CB2 is largely found on cells of immune origin. This minireview highlights the role of CB1 in excitotoxic assaults in the brain and its potential to limit addiction liability. In addition, it will examine the relationship between receptor activity and stimulation of insulin release from pancreatic ?-cells, insulin resistance, and feeding behavior leading toward obesity. The roles of CB2 in the neuropathology of amyotrophic lateral sclerosis and in the central manifestations of chronic HIV infection potentially converge at inflammatory cell activation, thereby providing an opportunity for intervention. Last, CB2 modulation is discussed in the context of an experimental model of postmenopausal osteoporosis. Achieving exquisite receptor selectivity and elucidating the mechanisms underlying receptor inhibition and activation will be essential for the development of the next generation of cannabinergic-based therapeutic agents. |*Translational Research, Biomedical [MESH] |Cannabinoid Receptor Modulators/*therapeutic use [MESH] |Disease [MESH] |Humans [MESH] |Neuroprotection [MESH] |Receptor, Cannabinoid, CB1/chemistry/metabolism [MESH]Minireview: From the bench, toward the clinic: therapeutic opportuniti(epmc).pdf DeepDyve Pubget Overpricing