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10.1016/j.cell.2015.04.002 http://scihub22266oqcxt.onion/10.1016/j.cell.2015.04.002 C4447213!4447213!25981667     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2015 ; 161 (5): 1138-51 Nephropedia Template TP {{tp|p=25981667|t=2015. The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation |pdf=|usr=}}{{25981667}} gab.com Text The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=25981667 #FOAvip The circadian timing system synchronizes cellular function by coordinating rhythmic transcription via a transcription-translational feedback loop. How the circadian system regulates gene expression at the translational level remains a mystery. Here, we show that the key circadian transcription factor BMAL1 associates with the translational machinery in the cytosol and promotes protein synthesis. The mTOR-effector kinase, ribosomal S6 protein kinase 1 (S6K1), an important regulator of translation, rhythmically phosphorylates BMAL1 at an evolutionarily conserved site. S6K1-mediated phosphorylation is critical for BMAL1 to both associate with the translational machinery and stimulate protein synthesis. Protein synthesis rates demonstrate circadian oscillations dependent on BMAL1. Thus, in addition to its critical role in circadian transcription, BMAL1 is a translation factor that links circadian timing and the mTOR signaling pathway. More broadly, these results expand the role of the circadian clock to the regulation of protein synthesis. Twit Text FOAVip The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=25981667 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25981667 #FOAvip English Wikipedia <ref>{{Cite pmid|25981667}}</ref> The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation #MMPMID25981667 Lipton JO; Yuan ED; Boyle LM; Ebrahimi-Fakhari D; Kwiatkowski E; Nathan A; Güttler T; Davis F; Asara JM; Sahin M Cell 2015[May]; 161 (5): 1138-51 PMID25981667show ga The circadian timing system synchronizes cellular function by coordinating rhythmic transcription via a transcription-translational feedback loop. How the circadian system regulates gene expression at the translational level remains a mystery. Here, we show that the key circadian transcription factor BMAL1 associates with the translational machinery in the cytosol and promotes protein synthesis. The mTOR-effector kinase, ribosomal S6 protein kinase 1 (S6K1), an important regulator of translation, rhythmically phosphorylates BMAL1 at an evolutionarily conserved site. S6K1-mediated phosphorylation is critical for BMAL1 to both associate with the translational machinery and stimulate protein synthesis. Protein synthesis rates demonstrate circadian oscillations dependent on BMAL1. Thus, in addition to its critical role in circadian transcription, BMAL1 is a translation factor that links circadian timing and the mTOR signaling pathway. More broadly, these results expand the role of the circadian clock to the regulation of protein synthesis. äThe Circadian Protein BMAL1 Regulates Translation in Response to S6K1-(epmc).pdf DeepDyve Pubget Overpricing