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http://scihub22266oqcxt.onion/ C4447073!4447073!26064789     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Cardiovasc+Dis 2015 ; 5 (1): 1-18 Nephropedia Template TP {{tp|p=26064789|t=2015. The COP9 signalosome and cullin-RING ligases in the heart |pdf=|usr=}}{{26064789}} gab.com Text The COP9 signalosome and cullin-RING ligases in the heart JO: Am J Cardiovasc Dis http://www.kidney.de/pget.php?&tw=1&pmid=26064789 #FOAvip Alteration of ubiquitin-proteasome system (UPS) mediated protein degradation has been implicated in the progression from a large subset of heart disease to congestive heart failure, rendering it extremely important to elucidate the cellular and molecular mechanism by which the UPS is regulated. Cullin-RING ligases (CRLs) represent the largest family of ubiquitin ligases crucial for UPS-dependent proteolysis. Serving as a cullin deneddylase, the COP9 signalosome (CSN) regulates the activity and assembly of CRLs. In the past several years, emerging studies have begun to unveil the role of the CSN and some of the CRLs in cardiomyocytes or the heart under physiological and pathological conditions. This review article will highlight and analyze these recent progresses and provide the author?s perspective on the future directions for this research field. Twit Text FOAVip The COP9 signalosome and cullin-RING ligases in the heart ????Am J Cardiovasc Dis http://www.kidney.de/pget.php?&tw=1&pmid=26064789 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26064789 #FOAvip English Wikipedia <ref>{{Cite pmid|26064789}}</ref> The COP9 signalosome and cullin-RING ligases in the heart #MMPMID26064789 Wang X; Martin DS Am J Cardiovasc Dis 2015[]; 5 (1): 1-18 PMID26064789show ga Alteration of ubiquitin-proteasome system (UPS) mediated protein degradation has been implicated in the progression from a large subset of heart disease to congestive heart failure, rendering it extremely important to elucidate the cellular and molecular mechanism by which the UPS is regulated. Cullin-RING ligases (CRLs) represent the largest family of ubiquitin ligases crucial for UPS-dependent proteolysis. Serving as a cullin deneddylase, the COP9 signalosome (CSN) regulates the activity and assembly of CRLs. In the past several years, emerging studies have begun to unveil the role of the CSN and some of the CRLs in cardiomyocytes or the heart under physiological and pathological conditions. This review article will highlight and analyze these recent progresses and provide the author?s perspective on the future directions for this research field. äThe COP9 signalosome and cullin-RING ligases in the heart (epmc).pdf DeepDyve Pubget Overpricing