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10.1038/srep10453 http://scihub22266oqcxt.onion/10.1038/srep10453 C4447071!4447071 !26020416     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26020416 &cmd=llinks): Failed to open stream: HTTP request failed! 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L-cystathionine inhibits oxidized low density lipoprotein-induced THP-1-derived macrophage inflammatory cytokine monocyte chemoattractant protein-1 generation via the NF-?B pathway |pdf=|usr=}}{{26020416 }} gab.com Text L-cystathionine inhibits oxidized low density lipoprotein-induced THP-1-derived macrophage inflammatory cytokine monocyte chemoattractant protein-1 generation via the NF- B pathway JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26020416 #FOAvip This study aimed to explore whether and how L-cystathionine had any regulatory effect on the inflammatory response in THP-1-derived macrophages cultured in vitro under oxidized low-density lipoprotein (ox-LDL) stimulation. The human monocyte line THP-1 cell was cultured in vitro and differentiated into macrophages after 24?hours of PMA induction. Macrophages were pretreated with L-cystathionine and then treated with ox-LDL. The results showed that compared with the controls, ox-LDL stimulation significantly upregulated the expression of THP-1-derived macrophage MCP-1 by enhancing NF-?B p65 phosphorylation, nuclear translocation and DNA binding with the MCP-1 promoter. Compared with the ox-LDL group, 0.3?mmol/L and 1.0?mmol/L L-cystathionine significantly inhibited the expression of THP-1-derived macrophage MCP-1. Mechanistically, 0.3?mmol/L and 1.0?mmol/L L-cystathionine suppressed phosphorylation and nuclear translocation of the NF-?B p65 protein, as well as the DNA binding activity and DNA binding level of NF-?B with the MCP-1 promoter, which resulted in a reduced THP-1-derived macrophage MCP-1 generation. This study suggests that L-cystathionine could inhibit the expression of MCP-1 in THP-1-derived macrophages induced by ox-LDL via inhibition of NF-?B p65 phosphorylation, nuclear translocation, and binding of the MCP-1 promoter sequence after entry into the nucleus. Twit Text FOAVip L-cystathionine inhibits oxidized low density lipoprotein-induced THP-1-derived macrophage inflammatory cytokine monocyte chemoattractant protein-1 generation via the NF- B pathway ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26020416 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26020416 #FOAvip English Wikipedia <ref>{{Cite pmid|26020416 }}</ref> L-cystathionine inhibits oxidized low density lipoprotein-induced THP-1-derived macrophage inflammatory cytokine monocyte chemoattractant protein-1 generation via the NF-?B pathway #MMPMID26020416 Zhu M ; Du J ; Liu AD ; Holmberg L ; Chen SY ; Bu D ; Tang C ; Jin H Sci Rep 2015[May]; 5 (ä): 10453 PMID26020416 show ga This study aimed to explore whether and how L-cystathionine had any regulatory effect on the inflammatory response in THP-1-derived macrophages cultured in vitro under oxidized low-density lipoprotein (ox-LDL) stimulation. The human monocyte line THP-1 cell was cultured in vitro and differentiated into macrophages after 24?hours of PMA induction. Macrophages were pretreated with L-cystathionine and then treated with ox-LDL. The results showed that compared with the controls, ox-LDL stimulation significantly upregulated the expression of THP-1-derived macrophage MCP-1 by enhancing NF-?B p65 phosphorylation, nuclear translocation and DNA binding with the MCP-1 promoter. Compared with the ox-LDL group, 0.3?mmol/L and 1.0?mmol/L L-cystathionine significantly inhibited the expression of THP-1-derived macrophage MCP-1. Mechanistically, 0.3?mmol/L and 1.0?mmol/L L-cystathionine suppressed phosphorylation and nuclear translocation of the NF-?B p65 protein, as well as the DNA binding activity and DNA binding level of NF-?B with the MCP-1 promoter, which resulted in a reduced THP-1-derived macrophage MCP-1 generation. This study suggests that L-cystathionine could inhibit the expression of MCP-1 in THP-1-derived macrophages induced by ox-LDL via inhibition of NF-?B p65 phosphorylation, nuclear translocation, and binding of the MCP-1 promoter sequence after entry into the nucleus. |Cell Differentiation/drug effects [MESH] |Cystathionine/administration & dosage [MESH] |Humans [MESH] |Inflammation/drug therapy/genetics/pathology [MESH] |Lipoproteins, LDL/administration & dosage/metabolism [MESH] |Macrophage Inflammatory Proteins/*genetics/metabolism [MESH] |Macrophages/drug effects/*metabolism/pathology [MESH] |Monocytes/drug effects/metabolism [MESH] |Phosphorylation/drug effects [MESH]L-cystathionine inhibits oxidized low density lipoprotein-induced THP-(epmc).pdf DeepDyve Pubget Overpricing