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2015 ; 5
(ä): 10476
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A compact photometer based on metal-waveguide-capillary: application to detecting
glucose of nanomolar concentration
#MMPMID26020222
Bai M
; Huang H
; Hao J
; Zhang J
; Wu H
; Qu B
Sci Rep
2015[May]; 5
(ä): 10476
PMID26020222
show ga
Trace analysis of liquid samples has wide applications in life science and
environmental monitor. In this paper, a compact and low-cost photometer based on
metal-waveguide-capillary (MWC) was developed for ultra-sensitive absorbance
detection. The optical-path can be greatly enhanced and much longer than the
physical length of MWC, because the light scattered by the rippled and smooth
metal sidewall can be confined inside the capillary regardless of the
incident-angle. For the photometer with a 7?cm long MWC, the detection limit is
improved ~3000 fold compared with that of commercial spectrophotometer with
1?cm-cuvette, owing to the novel nonlinear optical-path enhancement as well as
fast sample switching, and detecting glucose of a concentration as low as 5.12?nM
was realized with conventional chromogenic reagent.