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10.12703/P7-41 http://scihub22266oqcxt.onion/10.12703/P7-41 C4447048!4447048!26097714     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       F1000Prime+Rep 2015 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26097714|t=2015. Chicken or the egg: Warburg effect and mitochondrial dysfunction |pdf=|usr=}}{{26097714}} gab.com Text Chicken or the egg: Warburg effect and mitochondrial dysfunction JO: F1000Prime Rep http://www.kidney.de/pget.php?&tw=1&pmid=26097714 #FOAvip Compared with normal cells, cancer cells show alterations in many cellular processes, including energy metabolism. Studies on cancer metabolism started with Otto Warburg's observation at the beginning of the last century. According to Warburg, cancer cells rely on glycolysis more than mitochondrial respiration for energy production. Considering that glycolysis yields much less energy compared with mitochondrial respiration, Warburg hypothesized that mitochondria must be dysfunctional and this is the initiating factor for cancer formation. However, this hypothesis did not convince every scientist in the field. Some believed the opposite: the reduction in mitochondrial activity is a result of increased glycolysis. This discrepancy of opinions is ongoing. In this review, we will discuss the alterations in glycolysis, pyruvate metabolism, and the Krebs cycle in cancer cells and focus on cause and consequence. Twit Text FOAVip Chicken or the egg: Warburg effect and mitochondrial dysfunction ????F1000Prime Rep http://www.kidney.de/pget.php?&tw=1&pmid=26097714 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26097714 #FOAvip English Wikipedia <ref>{{Cite pmid|26097714}}</ref> Chicken or the egg: Warburg effect and mitochondrial dysfunction #MMPMID26097714 Senyilmaz D; Teleman AA F1000Prime Rep 2015[]; 7 (ä): ä PMID26097714show ga Compared with normal cells, cancer cells show alterations in many cellular processes, including energy metabolism. Studies on cancer metabolism started with Otto Warburg's observation at the beginning of the last century. According to Warburg, cancer cells rely on glycolysis more than mitochondrial respiration for energy production. Considering that glycolysis yields much less energy compared with mitochondrial respiration, Warburg hypothesized that mitochondria must be dysfunctional and this is the initiating factor for cancer formation. However, this hypothesis did not convince every scientist in the field. Some believed the opposite: the reduction in mitochondrial activity is a result of increased glycolysis. This discrepancy of opinions is ongoing. In this review, we will discuss the alterations in glycolysis, pyruvate metabolism, and the Krebs cycle in cancer cells and focus on cause and consequence. äChicken or the egg: Warburg effect and mitochondrial dysfunction (epmc).pdf DeepDyve Pubget Overpricing