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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 F1000Prime+Rep 2015 ; 7 (ä): ä Nephropedia Template TP
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Recent advances in renal transplantation: antibody-mediated rejection takes center stage #MMPMID26097724
Pouliquen E; Koenig A; Chen CC; Sicard A; Rabeyrin M; Morelon E; Dubois V; Thaunat O
F1000Prime Rep 2015[]; 7 (ä): ä PMID26097724show ga
Overlooked for decades, antibodies have taken center stage in renal transplantation and are now widely recognized as the first cause of allograft failure. Diagnosis of antibody-mediated rejection has considerably improved with identification of antibody-mediated lesions in graft biopsies and advances made in the detection of circulating donor-specific antibodies. Unfortunately, this progress has not yet translated into better outcomes for patients. Indeed, in the absence of a drug able to suppress antibody generation by plasma cells, available therapies can only slow down graft destruction. This review provides an overview of the current knowledge of antibody-mediated rejection and discusses future interesting research directions.