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10.12703/P7-51

http://scihub22266oqcxt.onion/10.12703/P7-51
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C4447042!4447042!26097724
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suck abstract from ncbi


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pmid26097724      F1000Prime+Rep 2015 ; 7 (ä): ä
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  • Recent advances in renal transplantation: antibody-mediated rejection takes center stage #MMPMID26097724
  • Pouliquen E; Koenig A; Chen CC; Sicard A; Rabeyrin M; Morelon E; Dubois V; Thaunat O
  • F1000Prime Rep 2015[]; 7 (ä): ä PMID26097724show ga
  • Overlooked for decades, antibodies have taken center stage in renal transplantation and are now widely recognized as the first cause of allograft failure. Diagnosis of antibody-mediated rejection has considerably improved with identification of antibody-mediated lesions in graft biopsies and advances made in the detection of circulating donor-specific antibodies. Unfortunately, this progress has not yet translated into better outcomes for patients. Indeed, in the absence of a drug able to suppress antibody generation by plasma cells, available therapies can only slow down graft destruction. This review provides an overview of the current knowledge of antibody-mediated rejection and discusses future interesting research directions.
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