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10.12703/P7-42

http://scihub22266oqcxt.onion/10.12703/P7-42
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C4447032!4447032!26097715
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suck abstract from ncbi

pmid26097715      F1000Prime+Rep 2015 ; 7 (ä): ä
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  • Mitochondria and apoptosis: emerging concepts #MMPMID26097715
  • Li MX; Dewson G
  • F1000Prime Rep 2015[]; 7 (ä): ä PMID26097715show ga
  • As mitochondria are the powerhouses of the cell, their damage during the cell suicide process of apoptosis is essentially responsible for cellular demise in most cells. A key family of proteins, the B-cell lymphoma-2 (BCL-2) family, determines the integrity of mitochondria in the face of apoptotic insult. A comprehensive understanding of the molecular details of how apoptosis is initiated and how it culminates is essential if apoptosis is to fulfil its undoubted potential as a therapeutic target to treat diseases ranging from cancer to neurodegenerative conditions. Recent advances have provided significant insight into the control of this fundamental process while prompting a re-evaluation of what was considered dogma in the field. Emerging evidence also points to a potential overarching control network that governs not only apoptosis but other fundamental mitochondrial processes, including mitochondrial fission/fusion and quality control.
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