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10.1681/ASN.2013111242 http://scihub22266oqcxt.onion/10.1681/ASN.2013111242 C4446865!4446865 !25573908     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25573908 &cmd=llinks): Failed to open stream: HTTP request failed! 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Clinical Features and Histology of Apolipoprotein L1-Associated Nephropathy in the FSGS Clinical Trial |pdf=|usr=}}{{25573908 }} gab.com Text Clinical Features and Histology of Apolipoprotein L1-Associated Nephropathy in the FSGS Clinical Trial JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25573908 #FOAvip Genetic variants in apolipoprotein L1 (APOL1) confer risk for kidney disease. We sought to better define the phenotype of APOL1-associated nephropathy. The FSGS Clinical Trial involved 138 children and young adults who were randomized to cyclosporin or mycophenolate mofetil plus pulse oral dexamethasone with a primary outcome of proteinuria remission. DNA was available from 94 subjects who were genotyped for APOL1 renal risk variants, with two risk alleles comprising the risk genotype. Two APOL1 risk alleles were present in 27 subjects, of whom four subjects did not self-identify as African American, and 23 of 32 (72%) self-identified African Americans. Individuals with the APOL1 risk genotype tended to present at an older age and had significantly lower baseline eGFR, more segmental glomerulosclerosis and total glomerulosclerosis, and more tubular atrophy/interstitial fibrosis. There were differences in renal histology, particularly more collapsing variants in those with the risk genotype (P=0.02), although this association was confounded by age. APOL1 risk genotype did not affect response to either treatment regimen. Individuals with the risk genotype were more likely to progress to ESRD (P<0.01). In conclusion, APOL1 risk genotypes are common in African-American subjects with primary FSGS and may also be present in individuals who do not self-identify as African American. APOL1 risk status is associated with lower kidney function, more glomerulosclerosis and interstitial fibrosis, and greater propensity to progress to ESRD. The APOL1 risk genotype did not influence proteinuria responses to cyclosporin or mycophenolate mofetil/dexamethasone. Twit Text FOAVip Clinical Features and Histology of Apolipoprotein L1-Associated Nephropathy in the FSGS Clinical Trial ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25573908 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25573908 #FOAvip English Wikipedia <ref>{{Cite pmid|25573908 }}</ref> Clinical Features and Histology of Apolipoprotein L1-Associated Nephropathy in the FSGS Clinical Trial #MMPMID25573908 Kopp JB ; Winkler CA ; Zhao X ; Radeva MK ; Gassman JJ ; D'Agati VD ; Nast CC ; Wei C ; Reiser J ; Guay-Woodford LM ; Pollak MR ; Hildebrandt F ; Moxey-Mims M ; Gipson DS ; Trachtman H ; Friedman AL ; Kaskel FJ J Am Soc Nephrol 2015[Jun]; 26 (6 ): 1443-8 PMID25573908 show ga Genetic variants in apolipoprotein L1 (APOL1) confer risk for kidney disease. We sought to better define the phenotype of APOL1-associated nephropathy. The FSGS Clinical Trial involved 138 children and young adults who were randomized to cyclosporin or mycophenolate mofetil plus pulse oral dexamethasone with a primary outcome of proteinuria remission. DNA was available from 94 subjects who were genotyped for APOL1 renal risk variants, with two risk alleles comprising the risk genotype. Two APOL1 risk alleles were present in 27 subjects, of whom four subjects did not self-identify as African American, and 23 of 32 (72%) self-identified African Americans. Individuals with the APOL1 risk genotype tended to present at an older age and had significantly lower baseline eGFR, more segmental glomerulosclerosis and total glomerulosclerosis, and more tubular atrophy/interstitial fibrosis. There were differences in renal histology, particularly more collapsing variants in those with the risk genotype (P=0.02), although this association was confounded by age. APOL1 risk genotype did not affect response to either treatment regimen. Individuals with the risk genotype were more likely to progress to ESRD (P<0.01). In conclusion, APOL1 risk genotypes are common in African-American subjects with primary FSGS and may also be present in individuals who do not self-identify as African American. APOL1 risk status is associated with lower kidney function, more glomerulosclerosis and interstitial fibrosis, and greater propensity to progress to ESRD. The APOL1 risk genotype did not influence proteinuria responses to cyclosporin or mycophenolate mofetil/dexamethasone. |Adolescent [MESH] |Adult [MESH] |Apolipoprotein L1 [MESH] |Apolipoproteins/*genetics [MESH] |Child [MESH] |Cyclosporins/*therapeutic use [MESH] |Dexamethasone/*therapeutic use [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Gene Expression Regulation [MESH] |Genotype [MESH] |Glomerulosclerosis, Focal Segmental/diagnosis/*drug therapy/*genetics/mortality [MESH] |Humans [MESH] |Kidney Function Tests [MESH] |Lipoproteins, HDL/*genetics [MESH] |Male [MESH] |Mycophenolic Acid/*analogs & derivatives/therapeutic use [MESH] |Prospective Studies [MESH] |Risk Assessment [MESH] |Severity of Illness Index [MESH] |Survival Rate [MESH] |Treatment Outcome [MESH]Clinical Features and Histology of Apolipoprotein L1-Associated Nephro(epmc).pdf DeepDyve Pubget Overpricing