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http://scihub22266oqcxt.onion/ C4446389!4446389!26069529     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Physiol+Pathophysiol+Pharmacol 2015 ; 7 (1): 54-60 Nephropedia Template TP {{tp|p=26069529|t=2015. The mTOR inhibitor sirolimus suppresses renal, hepatic, and cardiac tissue cellular respiration |pdf=|usr=}}{{26069529}} gab.com Text The mTOR inhibitor sirolimus suppresses renal, hepatic, and cardiac tissue cellular respiration JO: Int J Physiol Pathophysiol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26069529 #FOAvip The purpose of this in vitro study was to develop a useful biomarker (e.g., cellular respiration, or mitochondrial O2 consumption) for measuring activities of mTOR inhibitors. It measured the effects of commonly used immunosuppressants (sirolimus - rapamycin, tacrolimus, and cyclosporine) on cellular respiration in target tissues (kidney, liver, and heart) from C57BL/6 mice. The mammalian target of rapamycin (mTOR), a serine/threonine kinase that supports nutrient-dependent cell growth and survival, is known to control energy conversion processes within the mitochondria. Consistently, inhibitors of mTOR (e.g., rapamycin, also known as sirolimus or RapamuneŽ) have been shown to impair mitochondrial function. Inhibitors of the calcium-dependent serine/threonine phosphatase calcineurin (e.g., tacrolimus and cyclosporine), on the other hand, strictly prevent lymphokine production leading to a reduced T-cell function. Sirolimus (10 ?M) inhibited renal (22%, p = 0.002), hepatic (39%, p < 0.001), and cardiac (42%, p = 0.005) cellular respiration. Tacrolimus and cyclosporine had no or minimum effects on cellular respiration in these tissues. Thus, these results clearly demonstrate that impaired cellular respiration (bioenergetics) is a sensitive biomarker of the immunosuppressants that target mTOR. Twit Text FOAVip The mTOR inhibitor sirolimus suppresses renal, hepatic, and cardiac tissue cellular respiration ????Int J Physiol Pathophysiol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26069529 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26069529 #FOAvip English Wikipedia <ref>{{Cite pmid|26069529}}</ref> The mTOR inhibitor sirolimus suppresses renal, hepatic, and cardiac tissue cellular respiration #MMPMID26069529 Albawardi A; Almarzooqi S; Saraswathiamma D; Abdul-Kader HM; Souid AK; Alfazari AS Int J Physiol Pathophysiol Pharmacol 2015[]; 7 (1): 54-60 PMID26069529show ga The purpose of this in vitro study was to develop a useful biomarker (e.g., cellular respiration, or mitochondrial O2 consumption) for measuring activities of mTOR inhibitors. It measured the effects of commonly used immunosuppressants (sirolimus - rapamycin, tacrolimus, and cyclosporine) on cellular respiration in target tissues (kidney, liver, and heart) from C57BL/6 mice. The mammalian target of rapamycin (mTOR), a serine/threonine kinase that supports nutrient-dependent cell growth and survival, is known to control energy conversion processes within the mitochondria. Consistently, inhibitors of mTOR (e.g., rapamycin, also known as sirolimus or RapamuneŽ) have been shown to impair mitochondrial function. Inhibitors of the calcium-dependent serine/threonine phosphatase calcineurin (e.g., tacrolimus and cyclosporine), on the other hand, strictly prevent lymphokine production leading to a reduced T-cell function. Sirolimus (10 ?M) inhibited renal (22%, p = 0.002), hepatic (39%, p < 0.001), and cardiac (42%, p = 0.005) cellular respiration. Tacrolimus and cyclosporine had no or minimum effects on cellular respiration in these tissues. Thus, these results clearly demonstrate that impaired cellular respiration (bioenergetics) is a sensitive biomarker of the immunosuppressants that target mTOR. äThe mTOR inhibitor sirolimus suppresses renal, hepatic, and cardiac ti(epmc).pdf DeepDyve Pubget Overpricing