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http://scihub22266oqcxt.onion/ C4445958!4445958!25977188     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Discov+Med 2015 ; 19 (105): 255-62 Nephropedia Template TP {{tp|p=25977188|t=2015. The CRISPR/Cas9 genome editing methodology as a weapon against human viruses |pdf=|usr=}}{{25977188}} gab.com Text The CRISPR/Cas9 genome editing methodology as a weapon against human viruses JO: Discov Med http://www.kidney.de/pget.php?&tw=1&pmid=25977188 #FOAvip Viruses are a therapeutic challenge since their life cycles occur within the host cells and often utilize cellular proteins and hence it is harder to identify therapeutic targets compared to bacteria, which have their own cellular metabolism that is quite different from the host and often present unique targets such as enzymes, etc. Nevertheless, viral proteins may present useful targets for therapy, e.g., small molecule inhibitors of viral polymerases, or prevention, e.g., viral coat proteins for vaccination. However, some viruses may enter an inactive state of persistence or latency where no or very few viral proteins are produced. Thus, reagents that are specifically able to target nucleotide sequences within viral genomes would be a useful addition to the antiviral armamentarium. Such a reagent is the clustered regulatory interspaced short palindromic repeat (CRISPR)-associated 9 (Cas9) system, which is powerful, specific, and highly versatile and provides unprecedented control over genome editing. Here, we will discuss how CRISPR/Cas9 has been used against human viruses and future prospects for novel therapeutic approaches. Twit Text FOAVip The CRISPR/Cas9 genome editing methodology as a weapon against human viruses ????Discov Med http://www.kidney.de/pget.php?&tw=1&pmid=25977188 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25977188 #FOAvip English Wikipedia <ref>{{Cite pmid|25977188}}</ref> The CRISPR/Cas9 genome editing methodology as a weapon against human viruses #MMPMID25977188 White MK; Hu W; Khalili K Discov Med 2015[Apr]; 19 (105): 255-62 PMID25977188show ga Viruses are a therapeutic challenge since their life cycles occur within the host cells and often utilize cellular proteins and hence it is harder to identify therapeutic targets compared to bacteria, which have their own cellular metabolism that is quite different from the host and often present unique targets such as enzymes, etc. Nevertheless, viral proteins may present useful targets for therapy, e.g., small molecule inhibitors of viral polymerases, or prevention, e.g., viral coat proteins for vaccination. However, some viruses may enter an inactive state of persistence or latency where no or very few viral proteins are produced. Thus, reagents that are specifically able to target nucleotide sequences within viral genomes would be a useful addition to the antiviral armamentarium. Such a reagent is the clustered regulatory interspaced short palindromic repeat (CRISPR)-associated 9 (Cas9) system, which is powerful, specific, and highly versatile and provides unprecedented control over genome editing. Here, we will discuss how CRISPR/Cas9 has been used against human viruses and future prospects for novel therapeutic approaches. äThe CRISPR/Cas9 genome editing methodology as a weapon against human v(epmc).pdf DeepDyve Pubget Overpricing