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10.3389/fimmu.2015.00251 http://scihub22266oqcxt.onion/10.3389/fimmu.2015.00251 C4445385!4445385!26074919     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26074919|t=2015. B Cells use Conserved Polarity Cues to Regulate Their Antigen Processing and Presentation Functions |pdf=|usr=}}{{26074919}} gab.com Text B Cells use Conserved Polarity Cues to Regulate Their Antigen Processing and Presentation Functions JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26074919 #FOAvip The ability of B cells to produce high-affinity antibodies and to establish immunological memory in response to a wide range of pathogenic antigens is an essential part of the adaptive immune response. The initial step that triggers a humoral immune response involves the acquisition of antigens by B cells via their surface immunoglobulin, the B cell receptor (BCR). BCR-engaged antigens are transported into specialized lysosomal compartments where proteolysis and production of MHC class II-peptide complexes occur, a process referred to as antigen processing. Expression of MHC class II complexes at the B cell surface allows them to interact with T cells and to receive their help to become fully activated. In this review, we describe how B cells rely on conserved cell polarity mechanisms to coordinate local proteolytic secretion and mechanical forces at the B cell synapse enabling them to efficiently acquire and present extracellular antigens. We foresee that the mechanisms that dictate B cell activation can be used to tune B cell responses in the context of autoimmune diseases and cancer. Twit Text FOAVip B Cells use Conserved Polarity Cues to Regulate Their Antigen Processing and Presentation Functions ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26074919 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26074919 #FOAvip English Wikipedia <ref>{{Cite pmid|26074919}}</ref> B Cells use Conserved Polarity Cues to Regulate Their Antigen Processing and Presentation Functions #MMPMID26074919 Yuseff MI; Lennon-Duménil AM Front Immunol 2015[]; 6 (ä): ä PMID26074919show ga The ability of B cells to produce high-affinity antibodies and to establish immunological memory in response to a wide range of pathogenic antigens is an essential part of the adaptive immune response. The initial step that triggers a humoral immune response involves the acquisition of antigens by B cells via their surface immunoglobulin, the B cell receptor (BCR). BCR-engaged antigens are transported into specialized lysosomal compartments where proteolysis and production of MHC class II-peptide complexes occur, a process referred to as antigen processing. Expression of MHC class II complexes at the B cell surface allows them to interact with T cells and to receive their help to become fully activated. In this review, we describe how B cells rely on conserved cell polarity mechanisms to coordinate local proteolytic secretion and mechanical forces at the B cell synapse enabling them to efficiently acquire and present extracellular antigens. We foresee that the mechanisms that dictate B cell activation can be used to tune B cell responses in the context of autoimmune diseases and cancer. äB Cells use Conserved Polarity Cues to Regulate Their Antigen Processi(epmc).pdf DeepDyve Pubget Overpricing