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10.3389/fmicb.2015.00482 http://scihub22266oqcxt.onion/10.3389/fmicb.2015.00482 C4445044!4445044!26074888     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Microbiol 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26074888|t=2015. Plasmodium cellular effector mechanisms and the hepatic microenvironment |pdf=|usr=}}{{26074888}} gab.com Text Plasmodium cellular effector mechanisms and the hepatic microenvironment JO: Front Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=26074888 #FOAvip Plasmodium falciparum malaria remains one of the most serious health problems globally. Immunization with attenuated parasites elicits multiple cellular effector mechanisms capable of eliminating Plasmodium liver stages. However, malaria liver stage (LS) immunity is complex and the mechanisms effector T cells use to locate the few infected hepatocytes in the large liver in order to kill the intracellular LS parasites remain a mystery to date. Here, we review our current knowledge on the behavior of CD8 effector T cells in the hepatic microvasculature, in malaria and other hepatic infections. Taking into account the unique immunological and lymphogenic properties of the liver, we discuss whether classical granule-mediated cytotoxicity might eliminate infected hepatocytes via direct cell contact or whether cytokines might operate without cell?cell contact and kill Plasmodium LSs at a distance. A thorough understanding of the cellular effector mechanisms that lead to parasite death hence sterile protection is a prerequisite for the development of a successful malaria vaccine to protect the 40% of the world?s population currently at risk of Plasmodium infection. Twit Text FOAVip Plasmodium cellular effector mechanisms and the hepatic microenvironment ????Front Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=26074888 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26074888 #FOAvip English Wikipedia <ref>{{Cite pmid|26074888}}</ref> Plasmodium cellular effector mechanisms and the hepatic microenvironment #MMPMID26074888 Frevert U; Krzych U Front Microbiol 2015[]; 6 (ä): ä PMID26074888show ga Plasmodium falciparum malaria remains one of the most serious health problems globally. Immunization with attenuated parasites elicits multiple cellular effector mechanisms capable of eliminating Plasmodium liver stages. However, malaria liver stage (LS) immunity is complex and the mechanisms effector T cells use to locate the few infected hepatocytes in the large liver in order to kill the intracellular LS parasites remain a mystery to date. Here, we review our current knowledge on the behavior of CD8 effector T cells in the hepatic microvasculature, in malaria and other hepatic infections. Taking into account the unique immunological and lymphogenic properties of the liver, we discuss whether classical granule-mediated cytotoxicity might eliminate infected hepatocytes via direct cell contact or whether cytokines might operate without cell?cell contact and kill Plasmodium LSs at a distance. A thorough understanding of the cellular effector mechanisms that lead to parasite death hence sterile protection is a prerequisite for the development of a successful malaria vaccine to protect the 40% of the world?s population currently at risk of Plasmodium infection. äPlasmodium cellular effector mechanisms and the hepatic microenvironme(epmc).pdf DeepDyve Pubget Overpricing