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10.1038/srep10546 http://scihub22266oqcxt.onion/10.1038/srep10546 C4444958!4444958!26014289     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26014289|t=2015. Multiple MoS2 Transistors for Sensing Molecule Interaction Kinetics |pdf=|usr=}}{{26014289}} gab.com Text Multiple MoS2 Transistors for Sensing Molecule Interaction Kinetics JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26014289 #FOAvip Atomically layered transition metal dichalcogenides (TMDCs) exhibit a significant potential to enable next-generation low-cost transistor biosensors that permit single-molecule-level quantification of biomolecules. To realize such potential biosensing capability, device-oriented research is needed for calibrating the sensor responses to enable the quantification of the affinities/kinetics of biomolecule interactions. In this work, we demonstrated MoS2-based transistor biosensors capable of detecting tumor necrosis factor ? alpha (TNF-?) with a detection limit as low as 60?fM. Such a detection limit was achieved in both linear and subthreshold regimes of MoS2 transistors. In both regimes, all sets of transistors exhibited consistent calibrated responses with respect to TNF-? concentration, and they resulted in a standard curve, from which the equilibrium constant of the antibody-(TNF-?) pair was extracted to be KD?=?369?±?48?fM. Based on this calibrated sensor model, the time-dependent binding kinetics was also measured and the association/dissociation rates of the antibody-(TNF-?) pair were extracted to be (5.03?±?0.16)?×?108?M?1s?1 and (1.97?±?0.08)?×?10?4?s?1, respectively. This work advanced the critical device physics for leveraging the excellent electronic/structural properties of TMDCs in biosensing applications as well as the research capability in analyzing the biomolecule interactions with fM-level sensitivities. Twit Text FOAVip Multiple MoS2 Transistors for Sensing Molecule Interaction Kinetics ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26014289 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26014289 #FOAvip English Wikipedia <ref>{{Cite pmid|26014289}}</ref> Multiple MoS2 Transistors for Sensing Molecule Interaction Kinetics #MMPMID26014289 Nam H; Oh BR; Chen P; Chen M; Wi S; Wan W; Kurabayashi K; Liang X Sci Rep 2015[]; 5 (ä): ä PMID26014289show ga Atomically layered transition metal dichalcogenides (TMDCs) exhibit a significant potential to enable next-generation low-cost transistor biosensors that permit single-molecule-level quantification of biomolecules. To realize such potential biosensing capability, device-oriented research is needed for calibrating the sensor responses to enable the quantification of the affinities/kinetics of biomolecule interactions. In this work, we demonstrated MoS2-based transistor biosensors capable of detecting tumor necrosis factor ? alpha (TNF-?) with a detection limit as low as 60?fM. Such a detection limit was achieved in both linear and subthreshold regimes of MoS2 transistors. In both regimes, all sets of transistors exhibited consistent calibrated responses with respect to TNF-? concentration, and they resulted in a standard curve, from which the equilibrium constant of the antibody-(TNF-?) pair was extracted to be KD?=?369?±?48?fM. Based on this calibrated sensor model, the time-dependent binding kinetics was also measured and the association/dissociation rates of the antibody-(TNF-?) pair were extracted to be (5.03?±?0.16)?×?108?M?1s?1 and (1.97?±?0.08)?×?10?4?s?1, respectively. This work advanced the critical device physics for leveraging the excellent electronic/structural properties of TMDCs in biosensing applications as well as the research capability in analyzing the biomolecule interactions with fM-level sensitivities. äMultiple MoS2 Transistors for Sensing Molecule Interaction Kinetics (epmc).pdf DeepDyve Pubget Overpricing