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10.1038/srep10423 http://scihub22266oqcxt.onion/10.1038/srep10423 C4444957!4444957 !26013764     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26013764 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 10423 Nephropedia Template TP {{tp|p=26013764 |t=2015. Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology |pdf=|usr=}}{{26013764 }} gab.com Text Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26013764 #FOAvip Human PIWI-interacting RNAs (piRNAs) are known to be expressed in germline cells, functionally silencing LINEs and SINEs. Their expression patterns in somatic tissues are largely uncharted. We analyzed 6,260 human piRNA transcriptomes derived from non-malignant and tumour tissues from 11 organs. We discovered that only 273 of the 20,831 known piRNAs are expressed in somatic non-malignant tissues. However, expression patterns of these piRNAs were able to distinguish tissue-of-origin. A total of 522 piRNAs are expressed in corresponding tumour tissues, largely distinguishing tumour from non-malignant tissues in a cancer-type specific manner. Most expressed piRNAs mapped to known transcripts, contrary to "piRNA clusters" reported in germline cells. We showed that piRNA expression can delineate clinical features, such as histological subgroups, disease stages, and survival. PiRNAs common to many cancer types might represent a core gene-set that facilitates cancer growth, while piRNAs unique to individual cancer types likely contribute to cancer-specific biology. Twit Text FOAVip Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26013764 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26013764 #FOAvip English Wikipedia <ref>{{Cite pmid|26013764 }}</ref> Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology #MMPMID26013764 Martinez VD ; Vucic EA ; Thu KL ; Hubaux R ; Enfield KS ; Pikor LA ; Becker-Santos DD ; Brown CJ ; Lam S ; Lam WL Sci Rep 2015[May]; 5 (ä): 10423 PMID26013764 show ga Human PIWI-interacting RNAs (piRNAs) are known to be expressed in germline cells, functionally silencing LINEs and SINEs. Their expression patterns in somatic tissues are largely uncharted. We analyzed 6,260 human piRNA transcriptomes derived from non-malignant and tumour tissues from 11 organs. We discovered that only 273 of the 20,831 known piRNAs are expressed in somatic non-malignant tissues. However, expression patterns of these piRNAs were able to distinguish tissue-of-origin. A total of 522 piRNAs are expressed in corresponding tumour tissues, largely distinguishing tumour from non-malignant tissues in a cancer-type specific manner. Most expressed piRNAs mapped to known transcripts, contrary to "piRNA clusters" reported in germline cells. We showed that piRNA expression can delineate clinical features, such as histological subgroups, disease stages, and survival. PiRNAs common to many cancer types might represent a core gene-set that facilitates cancer growth, while piRNAs unique to individual cancer types likely contribute to cancer-specific biology. |Cluster Analysis [MESH] |Genome, Human [MESH] |Germ Cells/metabolism [MESH] |Humans [MESH] |Neoplasm Staging [MESH] |Neoplasms/*genetics/mortality/pathology [MESH] |Prognosis [MESH] |RNA, Neoplasm/genetics/metabolism [MESH] |RNA, Small Interfering/*metabolism [MESH] |Survival Analysis [MESH]Unique somatic and malignant expression patterns implicate PIWI-intera(epmc).pdf DeepDyve Pubget Overpricing