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2015 ; 2015
(ä): 231825
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Metformin Ameliorates Podocyte Damage by Restoring Renal Tissue Podocalyxin
Expression in Type 2 Diabetic Rats
#MMPMID26075281
Zhai L
; Gu J
; Yang D
; Wang W
; Ye S
J Diabetes Res
2015[]; 2015
(ä): 231825
PMID26075281
show ga
Podocalyxin (PCX) is a signature molecule of the glomerular podocyte and of
maintaining integrity of filtration function of glomerulus. The aim of this study
was to observe the effect of different doses of metformin on renal tissue PCX
expression in type 2 diabetic rats and clarify its protection on glomerular
podocytes. Type 2 diabetic Sprague-Dawley (SD) rats in which diabetes was induced
by high-fat diet/streptozotocin (HFD-STZ) were treated with different doses of
metformin (150, 300, and 500?mg/kg per day, resp.) for 8 weeks. Various
biochemical parameters, kidney histopathology, and renal tissue PCX expression
levels were examined. In type 2 diabetic rats, severe hyperglycemia and
hyperlipidemia were developed. Urinary albumin and PCX were markedly increased.
Diabetes induced significant alterations in renal glomerular structure. In
addition, protein and mRNA expression of renal tissue PCX were highly decreased.
However, treatment of rats with different doses of metformin restored all these
changes to a varying degree. These results suggested that metformin can
ameliorate glomerular podocyte damage in type 2 diabetic rats, which may be
partly associated with its role in restoring PCX expression and inhibiting
urinary excretion of PCX with dose dependence.