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10.1016/j.jacc.2015.03.549 http://scihub22266oqcxt.onion/10.1016/j.jacc.2015.03.549 C4444526!4444526 !26022821     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26022821 &cmd=llinks): Failed to open stream: HTTP request failed! 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Reducing In-Stent Restenosis: Therapeutic Manipulation of miRNA in Vascular Remodeling and Inflammation |pdf=|usr=}}{{26022821 }} gab.com Text Reducing In-Stent Restenosis: Therapeutic Manipulation of miRNA in Vascular Remodeling and Inflammation JO: J Am Coll Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=26022821 #FOAvip BACKGROUND: Drug-eluting stents reduce the incidence of in-stent restenosis, but they result in delayed arterial healing and are associated with a chronic inflammatory response and hypersensitivity reactions. Identifying novel interventions to enhance wound healing and reduce the inflammatory response may improve long-term clinical outcomes. Micro-ribonucleic acids (miRNAs) are noncoding small ribonucleic acids that play a prominent role in the initiation and resolution of inflammation after vascular injury. OBJECTIVES: This study sought to identify miRNA regulation and function after implantation of bare-metal and drug-eluting stents. METHODS: Pig, mouse, and in vitro models were used to investigate the role of miRNA in in-stent restenosis. RESULTS: We documented a subset of inflammatory miRNAs activated after stenting in pigs, including the miR-21 stem loop miRNAs. Genetic ablation of the miR-21 stem loop attenuated neointimal formation in mice post-stenting. This occurred via enhanced levels of anti-inflammatory M2 macrophages coupled with an impaired sensitivity of smooth muscle cells to respond to vascular activation. CONCLUSIONS: MiR-21 plays a prominent role in promoting vascular inflammation and remodeling after stent injury. MiRNA-mediated modulation of the inflammatory response post-stenting may have therapeutic potential to accelerate wound healing and enhance the clinical efficacy of stenting. Twit Text FOAVip Reducing In-Stent Restenosis: Therapeutic Manipulation of miRNA in Vascular Remodeling and Inflammation ????J Am Coll Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=26022821 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26022821 #FOAvip English Wikipedia <ref>{{Cite pmid|26022821 }}</ref> Reducing In-Stent Restenosis: Therapeutic Manipulation of miRNA in Vascular Remodeling and Inflammation #MMPMID26022821 McDonald RA ; Halliday CA ; Miller AM ; Diver LA ; Dakin RS ; Montgomery J ; McBride MW ; Kennedy S ; McClure JD ; Robertson KE ; Douglas G ; Channon KM ; Oldroyd KG ; Baker AH J Am Coll Cardiol 2015[Jun]; 65 (21 ): 2314-27 PMID26022821 show ga BACKGROUND: Drug-eluting stents reduce the incidence of in-stent restenosis, but they result in delayed arterial healing and are associated with a chronic inflammatory response and hypersensitivity reactions. Identifying novel interventions to enhance wound healing and reduce the inflammatory response may improve long-term clinical outcomes. Micro-ribonucleic acids (miRNAs) are noncoding small ribonucleic acids that play a prominent role in the initiation and resolution of inflammation after vascular injury. OBJECTIVES: This study sought to identify miRNA regulation and function after implantation of bare-metal and drug-eluting stents. METHODS: Pig, mouse, and in vitro models were used to investigate the role of miRNA in in-stent restenosis. RESULTS: We documented a subset of inflammatory miRNAs activated after stenting in pigs, including the miR-21 stem loop miRNAs. Genetic ablation of the miR-21 stem loop attenuated neointimal formation in mice post-stenting. This occurred via enhanced levels of anti-inflammatory M2 macrophages coupled with an impaired sensitivity of smooth muscle cells to respond to vascular activation. CONCLUSIONS: MiR-21 plays a prominent role in promoting vascular inflammation and remodeling after stent injury. MiRNA-mediated modulation of the inflammatory response post-stenting may have therapeutic potential to accelerate wound healing and enhance the clinical efficacy of stenting. |*Drug-Eluting Stents [MESH] |*Vascular Remodeling [MESH] |Animals [MESH] |Coronary Restenosis/*metabolism/prevention & control [MESH] |Inflammation/metabolism [MESH] |Male [MESH] |Mice, Knockout [MESH] |MicroRNAs/*metabolism [MESH] |Swine [MESH]Reducing In-Stent Restenosis: Therapeutic Manipulation of miRNA in Vas(epmc).pdf DeepDyve Pubget Overpricing