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10.1016/j.euroneuro.2014.06.008 http://scihub22266oqcxt.onion/10.1016/j.euroneuro.2014.06.008 C4444430!4444430!25088942     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+Neuropsychopharmacol 2014 ; 24 (12): 1954-60 Nephropedia Template TP {{tp|p=25088942|t=2014. Type 3 Diabetes is Sporadic Alzheimer?s disease: Mini-Review |pdf=|usr=}}{{25088942}} gab.com Text Type 3 Diabetes is Sporadic Alzheimer s disease: Mini-Review JO: Eur Neuropsychopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25088942 #FOAvip Alzheimer?s disease (AD) is the most common cause of dementia in North America. Growing evidence supports the concept that AD is a metabolic disease mediated by impairments in brain insulin responsiveness, glucose utilization, and energy metabolism, which lead to increased oxidative stress, inflammation, and worsening of insulin resistance. In addition, metabolic derangements directly contribute to the structural, functional, molecular, and biochemical abnormalities that characterize AD, including neuronal loss, synaptic disconnection, tau hyperphosphorylation, and amyloid-beta accumulation. Because the fundamental abnormalities in AD represent effects of brain insulin resistance and deficiency, and the molecular and biochemical consequences overlap with Type 1 and Type 2 diabetes, we suggest the term ?Type 3 diabetes? to account for the underlying abnormalities associated with AD-type neurodegeneration. In light of the rapid increases in sporadic AD prevalence rates and vastly expanded use of nitrites and nitrates in foods and agricultural products over the past 30?40 years, the potential role of nitrosamine exposures as mediators of Type 3 diabetes is discussed. Twit Text FOAVip Type 3 Diabetes is Sporadic Alzheimer s disease: Mini-Review ????Eur Neuropsychopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25088942 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25088942 #FOAvip English Wikipedia <ref>{{Cite pmid|25088942}}</ref> Type 3 Diabetes is Sporadic Alzheimer?s disease: Mini-Review #MMPMID25088942 de la Monte SM Eur Neuropsychopharmacol 2014[Dec]; 24 (12): 1954-60 PMID25088942show ga Alzheimer?s disease (AD) is the most common cause of dementia in North America. Growing evidence supports the concept that AD is a metabolic disease mediated by impairments in brain insulin responsiveness, glucose utilization, and energy metabolism, which lead to increased oxidative stress, inflammation, and worsening of insulin resistance. In addition, metabolic derangements directly contribute to the structural, functional, molecular, and biochemical abnormalities that characterize AD, including neuronal loss, synaptic disconnection, tau hyperphosphorylation, and amyloid-beta accumulation. Because the fundamental abnormalities in AD represent effects of brain insulin resistance and deficiency, and the molecular and biochemical consequences overlap with Type 1 and Type 2 diabetes, we suggest the term ?Type 3 diabetes? to account for the underlying abnormalities associated with AD-type neurodegeneration. In light of the rapid increases in sporadic AD prevalence rates and vastly expanded use of nitrites and nitrates in foods and agricultural products over the past 30?40 years, the potential role of nitrosamine exposures as mediators of Type 3 diabetes is discussed. äType 3 Diabetes is Sporadic Alzheimer?s disease: Mini-Review (epmc).pdf DeepDyve Pubget Overpricing