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10.1016/j.coi.2015.03.002 http://scihub22266oqcxt.onion/10.1016/j.coi.2015.03.002 C4444376!4444376!25771184     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Immunol 2015 ; 34 (ä): 91-8 Nephropedia Template TP {{tp|p=25771184|t=2015. New Insights into Type I Interferon and the Immunopathogenesis of Persistent Viral Infections |pdf=|usr=}}{{25771184}} gab.com Text New Insights into Type I Interferon and the Immunopathogenesis of Persistent Viral Infections JO: Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25771184 #FOAvip Most viruses generate potent T cell responses that rapidly control infection. However, certain viruses can subvert the immune response to establish persistent infections. The inability to clear virus induces an immunosuppressive program leading to the sustained expression of many immunoregulatory molecules that down-regulate T cell responses. Further, viral persistence is associated with multiple immune dysfunctions including lymphoid disorganization, defective antigen presentation, aberrant B cell responses and hypergammaglobulinemia. Although best known for its antiviral activity, recent data has highlighted the role of type I IFN (IFN-I) signaling as a central mediator of immunosuppression during viral persistence. It is also becoming increasingly apparent that many of the immune dysfunctions during persistent virus infection can be attributed directly or indirectly to the effects of chronic IFN-I signaling. This review explores the increasingly complex role of IFN-I in the regulation of immunity against persistently replicating virus infections and examines current and potential uses of IFN-I and blockade of IFN-I signaling to dampen chronic inflammation and activation in the clinic. Twit Text FOAVip New Insights into Type I Interferon and the Immunopathogenesis of Persistent Viral Infections ????Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25771184 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25771184 #FOAvip English Wikipedia <ref>{{Cite pmid|25771184}}</ref> New Insights into Type I Interferon and the Immunopathogenesis of Persistent Viral Infections #MMPMID25771184 Snell LM; Brooks DG Curr Opin Immunol 2015[Jun]; 34 (ä): 91-8 PMID25771184show ga Most viruses generate potent T cell responses that rapidly control infection. However, certain viruses can subvert the immune response to establish persistent infections. The inability to clear virus induces an immunosuppressive program leading to the sustained expression of many immunoregulatory molecules that down-regulate T cell responses. Further, viral persistence is associated with multiple immune dysfunctions including lymphoid disorganization, defective antigen presentation, aberrant B cell responses and hypergammaglobulinemia. Although best known for its antiviral activity, recent data has highlighted the role of type I IFN (IFN-I) signaling as a central mediator of immunosuppression during viral persistence. It is also becoming increasingly apparent that many of the immune dysfunctions during persistent virus infection can be attributed directly or indirectly to the effects of chronic IFN-I signaling. This review explores the increasingly complex role of IFN-I in the regulation of immunity against persistently replicating virus infections and examines current and potential uses of IFN-I and blockade of IFN-I signaling to dampen chronic inflammation and activation in the clinic. äNew Insights into Type I Interferon and the Immunopathogenesis of Pers(epmc).pdf DeepDyve Pubget Overpricing