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2015 ; 2015
(ä): 257628
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Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young
Adult with Fabry Disease
#MMPMID26064721
Trimarchi H
; Canzonieri R
; Muryan A
; Schiel A
; Araoz A
; Forrester M
; Karl A
; Lombi F
; Andrews J
; Pomeranz V
; Rengel T
; Zotta E
Case Rep Nephrol
2015[]; 2015
(ä): 257628
PMID26064721
show ga
The time for starting a patient with Fabry disease on enzyme replacement therapy
is still a matter of debate, particularly when no overt classical clinical signs
or symptoms are present. With respect to Fabry nephropathy, a dual problem
coexists: the reluctance of many nephrologists to start enzyme replacement
infusion until signs of renal disease appear as the appearance of proteinuria or
an elevation in serum creatinine and the lack of validated biomarkers of early
renal damage. In this regard, proteinuria is nowadays considered as an early and
appropriate marker of kidney disease and of cardiovascular morbidity and
mortality. However, in this report we demonstrate that podocyturia antedates the
classical appearance of proteinuria and could be considered as an even earlier
biomarker of kidney damage. Podocyturia may be a novel indication for the
initiation of therapy in Fabry disease.