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10.1161/CIRCRESAHA.116.305432

http://scihub22266oqcxt.onion/10.1161/CIRCRESAHA.116.305432
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C4443500!4443500!25999419
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suck abstract from ncbi


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pmid25999419      Circ+Res 2015 ; 116 (11): 1783-99
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  • Mitochondrial Reactive Oxygen Species at the Heart of the Matter: New Therapeutic Approaches for Cardiovascular Diseases #MMPMID25999419
  • Kornfeld OS; Hwang S; Disatnik MH; Chen CH; Qvit N; Mochly-Rosen D
  • Circ Res 2015[May]; 116 (11): 1783-99 PMID25999419show ga
  • Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases including multiple cardiovascular disorders. However, translation of ROS scavengers (anti-oxidants) into the clinic has not been successful. These anti-oxidants grossly reduce total levels of cellular ROS including ROS that participate in physiological signaling. In this review, we challenge the traditional anti-oxidant therapeutic approach that targets ROS directly with novel approaches that improve mitochondrial functions to more effectively treat cardiovascular diseases.
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