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10.1002/art.38747 http://scihub22266oqcxt.onion/10.1002/art.38747 C4443497!4443497 !24943488     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24943488 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Arthritis+Rheumatol 2014 ; 66 (10 ): 2881-91 Nephropedia Template TP {{tp|p=24943488 |t=2014. Contribution of mast cell-derived interleukin-1? to uric acid crystal-induced acute arthritis in mice |pdf=|usr=}}{{24943488 }} gab.com Text Contribution of mast cell-derived interleukin-1 to uric acid crystal-induced acute arthritis in mice JO: Arthritis Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=24943488 #FOAvip OBJECTIVE: Gouty arthritis is caused by the precipitation of monosodium urate monohydrate (MSU) crystals in the joints. While it has been reported that mast cells (MCs) infiltrate gouty tophi, little is known about the actual roles of MCs during acute attacks of gout. This study was undertaken to assess the role of MCs in a mouse model of MSU crystal-induced acute arthritis. METHODS: We assessed the effects of intraarticular (IA) injection of MSU crystals in various strains of mice with constitutive or inducible MC deficiency or in mice lacking interleukin-1? (IL-1?) or other elements of innate immunity. We also assessed the response to IA injection of MSU crystals in genetically MC-deficient mice after IA engraftment of wild-type or IL-1?(-/-) bone marrow-derived cultured MCs. RESULTS: MCs were found to augment acute tissue swelling following IA injection of MSU crystals in mice. IL-1? production by MCs contributed importantly to MSU crystal-induced tissue swelling, particularly during its early stages. Selective depletion of synovial MCs was able to diminish MSU crystal-induced acute inflammation in the joints. CONCLUSION: Our findings identify a previously unrecognized role of MCs and MC-derived IL-1? in the early stages of MSU crystal-induced acute arthritis in mice. Twit Text FOAVip Contribution of mast cell-derived interleukin-1 to uric acid crystal-induced acute arthritis in mice ????Arthritis Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=24943488 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24943488 #FOAvip English Wikipedia <ref>{{Cite pmid|24943488 }}</ref> Contribution of mast cell-derived interleukin-1? to uric acid crystal-induced acute arthritis in mice #MMPMID24943488 Reber LL ; Marichal T ; Sokolove J ; Starkl P ; Gaudenzio N ; Iwakura Y ; Karasuyama H ; Schwartz LB ; Robinson WH ; Tsai M ; Galli SJ Arthritis Rheumatol 2014[Oct]; 66 (10 ): 2881-91 PMID24943488 show ga OBJECTIVE: Gouty arthritis is caused by the precipitation of monosodium urate monohydrate (MSU) crystals in the joints. While it has been reported that mast cells (MCs) infiltrate gouty tophi, little is known about the actual roles of MCs during acute attacks of gout. This study was undertaken to assess the role of MCs in a mouse model of MSU crystal-induced acute arthritis. METHODS: We assessed the effects of intraarticular (IA) injection of MSU crystals in various strains of mice with constitutive or inducible MC deficiency or in mice lacking interleukin-1? (IL-1?) or other elements of innate immunity. We also assessed the response to IA injection of MSU crystals in genetically MC-deficient mice after IA engraftment of wild-type or IL-1?(-/-) bone marrow-derived cultured MCs. RESULTS: MCs were found to augment acute tissue swelling following IA injection of MSU crystals in mice. IL-1? production by MCs contributed importantly to MSU crystal-induced tissue swelling, particularly during its early stages. Selective depletion of synovial MCs was able to diminish MSU crystal-induced acute inflammation in the joints. CONCLUSION: Our findings identify a previously unrecognized role of MCs and MC-derived IL-1? in the early stages of MSU crystal-induced acute arthritis in mice. |*Uric Acid [MESH] |Animals [MESH] |Arthritis, Experimental/*immunology/metabolism [MESH] |Arthritis, Gouty/chemically induced/*immunology/metabolism [MESH] |Humans [MESH] |Immunity, Innate [MESH] |Inflammation/immunology/metabolism [MESH] |Interleukin-1beta/*metabolism [MESH] |Mast Cells/*metabolism [MESH] |Mice [MESH]Contribution of mast cell-derived interleukin-1? to uric acid crystal-(epmc).pdf DeepDyve Pubget Overpricing