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10.14348/molcells.2015.0034 http://scihub22266oqcxt.onion/10.14348/molcells.2015.0034 C4443278!4443278!25896254     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cells 2015 ; 38 (5): 381-9 Nephropedia Template TP {{tp|p=25896254|t=2015. Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach |pdf=|usr=}}{{25896254}} gab.com Text Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach JO: Mol Cells http://www.kidney.de/pget.php?&tw=1&pmid=25896254 #FOAvip Autophagy is a lysosome-dependent intracellular degradation process that allows recycling of cytoplasmic constituents into bioenergetic and biosynthetic materials for maintenance of homeostasis. Since the function of autophagy is particularly important in various stress conditions, perturbation of autophagy can lead to cellular dysfunction and diseases. Accumulation of abnormal protein aggregates, a common cause of neurodegenerative diseases, can be reduced through autophagic degradation. Recent studies have revealed defects in autophagy in most cases of neurodegenerative disorders. Moreover, deregulated excessive autophagy can also cause neurodegeneration. Thus, healthy activation of autophagy is essential for therapeutic approaches in neurodegenerative diseases and many autophagy-regulating compounds are under development for therapeutic purposes. This review describes the overall role of autophagy in neurodegeneration, focusing on various therapeutic strategies for modulating specific stages of autophagy and on the current status of drug development. Twit Text FOAVip Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach ????Mol Cells http://www.kidney.de/pget.php?&tw=1&pmid=25896254 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25896254 #FOAvip English Wikipedia <ref>{{Cite pmid|25896254}}</ref> Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach #MMPMID25896254 Nah J; Yuan J; Jung YK Mol Cells 2015[May]; 38 (5): 381-9 PMID25896254show ga Autophagy is a lysosome-dependent intracellular degradation process that allows recycling of cytoplasmic constituents into bioenergetic and biosynthetic materials for maintenance of homeostasis. Since the function of autophagy is particularly important in various stress conditions, perturbation of autophagy can lead to cellular dysfunction and diseases. Accumulation of abnormal protein aggregates, a common cause of neurodegenerative diseases, can be reduced through autophagic degradation. Recent studies have revealed defects in autophagy in most cases of neurodegenerative disorders. Moreover, deregulated excessive autophagy can also cause neurodegeneration. Thus, healthy activation of autophagy is essential for therapeutic approaches in neurodegenerative diseases and many autophagy-regulating compounds are under development for therapeutic purposes. This review describes the overall role of autophagy in neurodegeneration, focusing on various therapeutic strategies for modulating specific stages of autophagy and on the current status of drug development. äAutophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic(epmc).pdf DeepDyve Pubget Overpricing