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Astragalus polysaccharide suppresses excessive collagen accumulation in a murine model of bleomycin-induced scleroderma |pdf=|usr=}}{{26064283 }} gab.com Text Astragalus polysaccharide suppresses excessive collagen accumulation in a murine model of bleomycin-induced scleroderma JO: Int J Clin Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=26064283 #FOAvip Systemic scleroderma is an autoimmune disease characterized by fibrotic changes in skin and other organs involving excessive collagen deposition. The transforming growth factor-? (TGF-?) signaling pathway plays a key role in the fibrotic process in systemic scleroderma (SSc). Astragalus polysaccharides (APS) isolated from one of the Chinese herbs, Astragalus mongholicus, are known to have a variety of immunomodulatory activities. The present study aimed to investigate the effect of APS on TGF-? signaling and its potential mechanism using a murine model of bleomycin-induced scleroderma. Scleroderma was induced in C3H/He N mice by subcutaneous bleomycin injections daily for 21 days. Skin samples were obtained 7, 14, and 21 days and TGF-?1, Smad2, Smad3 mRNA expression was observed by real time PCR. The hydroxyproline content which consistent with the collagen content in skin samples from the BLM-injected group was significantly higher than the PBS group, and corresponded with dermal thickening at the injection site. In contrast, mice treated with APS after initiating BLM injection showed obviously lesser collagen content. Increased TGF-?1, Smad2, Smad3 mRNA expression were also observed in the BLM group. TGF-?1, Smad2, Smad3 expression was significantly lesser for the APS group than for the BLM group. In contrast, TGF-?1 mRNA expression was remarkably inhibited by APS. These results suggest that APS treatment may inhibit TGF-?1 production, and thus could be a potential drug for managing fibrotic disorders such as SSc. Twit Text FOAVip Astragalus polysaccharide suppresses excessive collagen accumulation in a murine model of bleomycin-induced scleroderma ????Int J Clin Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=26064283 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26064283 #FOAvip English Wikipedia <ref>{{Cite pmid|26064283 }}</ref> Astragalus polysaccharide suppresses excessive collagen accumulation in a murine model of bleomycin-induced scleroderma #MMPMID26064283 Hao ZF ; Su YM ; Liu JY ; Wang CM ; Yang RY Int J Clin Exp Med 2015[]; 8 (3 ): 3848-54 PMID26064283 show ga Systemic scleroderma is an autoimmune disease characterized by fibrotic changes in skin and other organs involving excessive collagen deposition. The transforming growth factor-? (TGF-?) signaling pathway plays a key role in the fibrotic process in systemic scleroderma (SSc). Astragalus polysaccharides (APS) isolated from one of the Chinese herbs, Astragalus mongholicus, are known to have a variety of immunomodulatory activities. The present study aimed to investigate the effect of APS on TGF-? signaling and its potential mechanism using a murine model of bleomycin-induced scleroderma. Scleroderma was induced in C3H/He N mice by subcutaneous bleomycin injections daily for 21 days. Skin samples were obtained 7, 14, and 21 days and TGF-?1, Smad2, Smad3 mRNA expression was observed by real time PCR. The hydroxyproline content which consistent with the collagen content in skin samples from the BLM-injected group was significantly higher than the PBS group, and corresponded with dermal thickening at the injection site. In contrast, mice treated with APS after initiating BLM injection showed obviously lesser collagen content. Increased TGF-?1, Smad2, Smad3 mRNA expression were also observed in the BLM group. TGF-?1, Smad2, Smad3 expression was significantly lesser for the APS group than for the BLM group. In contrast, TGF-?1 mRNA expression was remarkably inhibited by APS. These results suggest that APS treatment may inhibit TGF-?1 production, and thus could be a potential drug for managing fibrotic disorders such as SSc. äAstragalus polysaccharide suppresses excessive collagen accumulation i(epmc).pdf DeepDyve Pubget Overpricing