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10.1089/humc.2014.155

http://scihub22266oqcxt.onion/10.1089/humc.2014.155
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C4442585!4442585!25671556
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suck abstract from ncbi

pmid25671556      Hum+Gene+Ther+Clin+Dev 2015 ; 26 (1): 15-26
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  • Dog Models for Blinding Inherited Retinal Dystrophies #MMPMID25671556
  • Petersen-Jones SM; Komáromy AM
  • Hum Gene Ther Clin Dev 2015[Mar]; 26 (1): 15-26 PMID25671556show ga
  • Spontaneous canine models exist for several inherited retinal dystrophies. This review will summarize the models and indicate where they have been used in translational gene therapy trials. The RPE65 gene therapy trials to treat childhood blindness are a good example of how studies in dogs have contributed to therapy development. Outcomes in human clinical trials are compared and contrasted with the result of the preclinical dog trials.
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