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10.1155/2015/593407 http://scihub22266oqcxt.onion/10.1155/2015/593407 C4442300!4442300!26078809     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oxid+Med+Cell+Longev 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=26078809|t=2015. Hydrogen Sulfide as a Potential Therapeutic Target in Fibrosis |pdf=|usr=}}{{26078809}} gab.com Text Hydrogen Sulfide as a Potential Therapeutic Target in Fibrosis JO: Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=26078809 #FOAvip Hydrogen sulfide (H2S), produced endogenously by the activation of two major H2S-generating enzymes (cystathionine ?-synthase and cystathionine ?-lyase), plays important regulatory roles in different physiologic and pathologic conditions. The abnormal metabolism of H2S is associated with fibrosis pathogenesis, causing damage in structure and function of different organs. A number of in vivo and in vitro studies have shown that both endogenous H2S level and the expressions of H2S-generating enzymes in plasma and tissues are significantly downregulated during fibrosis. Supplement with exogenous H2S mitigates the severity of fibrosis in various experimental animal models. The protective role of H2S in the development of fibrosis is primarily attributed to its antioxidation, antiapoptosis, anti-inflammation, proangiogenesis, and inhibition of fibroblasts activities. Future studies might focus on the potential to intervene fibrosis by targeting the pathway of endogenous H2S-producing enzymes and H2S itself. Twit Text FOAVip Hydrogen Sulfide as a Potential Therapeutic Target in Fibrosis ????Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=26078809 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26078809 #FOAvip English Wikipedia <ref>{{Cite pmid|26078809}}</ref> Hydrogen Sulfide as a Potential Therapeutic Target in Fibrosis #MMPMID26078809 Zhang S; Pan C; Zhou F; Yuan Z; Wang H; Cui W; Zhang G Oxid Med Cell Longev 2015[]; 2015 (ä): ä PMID26078809show ga Hydrogen sulfide (H2S), produced endogenously by the activation of two major H2S-generating enzymes (cystathionine ?-synthase and cystathionine ?-lyase), plays important regulatory roles in different physiologic and pathologic conditions. The abnormal metabolism of H2S is associated with fibrosis pathogenesis, causing damage in structure and function of different organs. A number of in vivo and in vitro studies have shown that both endogenous H2S level and the expressions of H2S-generating enzymes in plasma and tissues are significantly downregulated during fibrosis. Supplement with exogenous H2S mitigates the severity of fibrosis in various experimental animal models. The protective role of H2S in the development of fibrosis is primarily attributed to its antioxidation, antiapoptosis, anti-inflammation, proangiogenesis, and inhibition of fibroblasts activities. Future studies might focus on the potential to intervene fibrosis by targeting the pathway of endogenous H2S-producing enzymes and H2S itself. äHydrogen Sulfide as a Potential Therapeutic Target in Fibrosis (epmc).pdf DeepDyve Pubget Overpricing