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10.1155/2015/842108

http://scihub22266oqcxt.onion/10.1155/2015/842108
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C4442287!4442287!26078820
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suck abstract from ncbi


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pmid26078820      Oxid+Med+Cell+Longev 2015 ; 2015 (ä): ä
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  • Rimonabant Improves Oxidative/Nitrosative Stress in Mice with Nonalcoholic Fatty Liver Disease #MMPMID26078820
  • Jorga?evi? B; Mladenovi? D; Ninkovi? M; Veskovi? M; Dragutinovi? V; Vatazevi? A; Vu?evi? D; Je?i? Vuki?evi? R; Radosavljevi? T
  • Oxid Med Cell Longev 2015[]; 2015 (ä): ä PMID26078820show ga
  • The present study deals with the effects of rimonabant on oxidative/nitrosative stress in high diet- (HFD-) induced experimental nonalcoholic fatty liver disease (NAFLD). Male mice C57BL/6 were divided into the following groups: control group fed with control diet for 20 weeks (C; n = 6); group fed with HFD for 20 weeks (HF; n = 6); group fed with standard diet and treated with rimonabant after 18 weeks (R; n = 9); group fed with HFD and treated with rimonabant after 18 weeks (HFR; n = 10). Daily dose of rimonabant (10?mg/kg) was administered to HFR and R group by oral gavage for two weeks. Treatment induced a decrease in hepatic malondialdehyde concentration in HFR group compared to HF group (P < 0.01). The concentration of nitrites + nitrates in liver was decreased in HFR group compared to HF group (P < 0.01). Liver content of reduced glutathione was higher in HFR group compared to HF group (P < 0.01). Total liver superoxide dismutase activity in HFR group was decreased in comparison with HF group (P < 0.01). It was found that rimonabant may influence hepatic iron, zinc, copper, and manganese status. Our study indicates potential usefulness of cannabinoid receptor type 1 blockade in the treatment of HFD-induced NAFLD.
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