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10.1016/j.febslet.2015.04.047 http://scihub22266oqcxt.onion/10.1016/j.febslet.2015.04.047 C4442043!4442043 !25959868     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25959868 &cmd=llinks): Failed to open stream: HTTP request failed! 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Yes-Associated Protein is up-regulated by mechanical overload and is sufficient to induce skeletal muscle hypertrophy |pdf=|usr=}}{{25959868 }} gab.com Text Yes-Associated Protein is up-regulated by mechanical overload and is sufficient to induce skeletal muscle hypertrophy JO: FEBS Lett http://www.kidney.de/pget.php?&tw=1&pmid=25959868 #FOAvip Mechanically-induced skeletal muscle growth is regulated by mammalian/mechanistic target of rapamycin complex 1 (mTORC1). Yes-Associated Protein (YAP) is a mechanically-sensitive, and growth-related, transcriptional co-activator that can regulate mTORC1. Here we show that, in skeletal muscle, mechanical overload promotes an increase in YAP expression; however, the time course of YAP expression is markedly different from that of mTORC1 activation. We also show that the overexpression of YAP induces hypertrophy via an mTORC1-independent mechanism. Finally, we provide preliminary evidence of possible mediators of YAP-induced hypertrophy (e.g. increased MyoD and c-Myc expression, and decreased Smad2/3 activity and muscle ring finger 1 (MuRF1) expression). Twit Text FOAVip Yes-Associated Protein is up-regulated by mechanical overload and is sufficient to induce skeletal muscle hypertrophy ????FEBS Lett http://www.kidney.de/pget.php?&tw=1&pmid=25959868 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25959868 #FOAvip English Wikipedia <ref>{{Cite pmid|25959868 }}</ref> Yes-Associated Protein is up-regulated by mechanical overload and is sufficient to induce skeletal muscle hypertrophy #MMPMID25959868 Goodman CA ; Dietz JM ; Jacobs BL ; McNally RM ; You JS ; Hornberger TA FEBS Lett 2015[Jun]; 589 (13 ): 1491-7 PMID25959868 show ga Mechanically-induced skeletal muscle growth is regulated by mammalian/mechanistic target of rapamycin complex 1 (mTORC1). Yes-Associated Protein (YAP) is a mechanically-sensitive, and growth-related, transcriptional co-activator that can regulate mTORC1. Here we show that, in skeletal muscle, mechanical overload promotes an increase in YAP expression; however, the time course of YAP expression is markedly different from that of mTORC1 activation. We also show that the overexpression of YAP induces hypertrophy via an mTORC1-independent mechanism. Finally, we provide preliminary evidence of possible mediators of YAP-induced hypertrophy (e.g. increased MyoD and c-Myc expression, and decreased Smad2/3 activity and muscle ring finger 1 (MuRF1) expression). |*Up-Regulation [MESH] |Adaptor Proteins, Signal Transducing/genetics/*metabolism [MESH] |Animals [MESH] |Blotting, Western [MESH] |Cell Cycle Proteins [MESH] |Female [MESH] |Gene Expression Regulation [MESH] |Hypertrophy [MESH] |Male [MESH] |Mechanistic Target of Rapamycin Complex 1 [MESH] |Mice [MESH] |Microscopy, Fluorescence [MESH] |Multiprotein Complexes/metabolism [MESH] |Muscle Proteins/genetics [MESH] |Muscle, Skeletal/*metabolism/pathology [MESH] |MyoD Protein/genetics [MESH] |Phosphoproteins/genetics/*metabolism [MESH] |Promoter Regions, Genetic/genetics [MESH] |Proto-Oncogene Proteins c-myc/genetics [MESH] |Signal Transduction [MESH] |Smad2 Protein/metabolism [MESH] |Smad3 Protein/metabolism [MESH] |Stress, Mechanical [MESH] |TOR Serine-Threonine Kinases/metabolism [MESH] |Tripartite Motif Proteins [MESH] |Ubiquitin-Protein Ligases/genetics [MESH]Yes-Associated Protein is up-regulated by mechanical overload and is s(epmc).pdf DeepDyve Pubget Overpricing