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2015 ; 51
(18
): 3723-34
Nephropedia Template TP
gab.com Text
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English Wikipedia
A survey of advancements in nucleic acid-based logic gates and computing for
applications in biotechnology and biomedicine
#MMPMID25597946
Wu C
; Wan S
; Hou W
; Zhang L
; Xu J
; Cui C
; Wang Y
; Hu J
; Tan W
Chem Commun (Camb)
2015[Mar]; 51
(18
): 3723-34
PMID25597946
show ga
Nucleic acid-based logic devices were first introduced in 1994. Since then,
science has seen the emergence of new logic systems for mimicking mathematical
functions, diagnosing disease and even imitating biological systems. The unique
features of nucleic acids, such as facile and high-throughput synthesis,
Watson-Crick complementary base pairing, and predictable structures, together
with the aid of programming design, have led to the widespread applications of
nucleic acids (NA) for logic gate and computing in biotechnology and biomedicine.
In this feature article, the development of in vitro NA logic systems will be
discussed, as well as the expansion of such systems using various input molecules
for potential cellular, or even in vivo, applications.